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DRD2 Rabbit pAb (bs-1008R)  
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產(chǎn)品編號 bs-1008R
英文名稱 DRD2 Rabbit pAb
中文名稱 多巴胺受體D2抗體
別    名 DRD2_HUMAN; D(2) dopamine receptor; Dopamine D2 receptor; dopamine receptor D2; D2R; D2DR;  
Specific References  (11)     |     bs-1008R has been referenced in 11 publications.
[IF=11.685] Kristine Elisabeth Eberhard. et al. Neurotransmitter and Neurotransmitter Receptor Expression in the Saccule of the Human Vestibular System. Prog Neurobiol. 2022 Jan;:102238  IHC ;  Human.  
[IF=8.46] Zhang, Q. B., et al. "Moderate swimming suppressed the growth and metastasis of the transplanted liver cancer in mice model: with reference to nervous system." Oncogene (2016).  WB ;  Human.  
[IF=4.181] Bai L et al. m6A demethylase FTO regulates dopaminergic neurotransmission deficits caused by arsenite.Toxicol Sci. 2018 Oct 1;165(2):431-446.  WB ;  Mouse.  
[IF=3.26] Salgado, R., et al. "Perfluorooctane sulfonate (PFOS) exposure could modify the dopaminergic system in several limbic brain regions." Toxicology Letters(2015).  WB ;  Rat.  
[IF=2.88] Yano, Shigetoshi, et al. "Mixed pituitary gangliocytom and prolactinoma resistant to the cabergoline treatment: A case report." World Neurosurgery(2016).  IHC-P ;  Human.  
[IF=2.629] Bian Li-hua. et al. Nardosinone Alleviates Parkinson’s Disease Symptoms in Mice by Regulating Dopamine D2 Receptor. Evid-Based Compl Alt. 2021;2021:6686965  WB ;  Mouse.  
[IF=2.35] Xu, Jiao-jiao, et al. "Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells." Acta Pharmacologica Sinica (2014).  WB ;  Human.  
[IF=1.966] Tian L et al. Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems. J Nat Med. 2019 Nov 25.  IHC-P ;  rat&mink.  
[IF=1.44] Hu et al. Increased extracellular dopamine and 5-hydroxytryptamine levels contribute to enhanced subthalamic nucleus neural activity during exhausting exercise. (2015) Biol.Sport. 32:187-92  IHC ;  Rat.  
[IF=0.93] Mao, Min, et al. "Dopamine D2 receptor blocker thioridazine induces cell death in human uterine cervical carcinoma cell line SiHa." Journal of Obstetrics and Gynaecology Research (2015).  IHC-P ;  Human.  
[IF=0.64] Qian, Weibin, et al. "Effect of Gingerol on Cisplatin-Induced Pica Analogous to Emesis Via Modulating Expressions of Dopamine 2 Receptor, Dopamine Transporter and Tyrosine Hydroxylase in the Vomiting Model of Rats."Yonago Acta medica 59 (2016): 100-110.  IHC-F ;  Rat.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞膜受體  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat (predicted: Human)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 51 kDa
檢測分子量
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DRD2: 201-300/443 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]

Function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Subcellular Location:
Cell membrane.

DISEASE:
Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P14416

Gene ID:
1813

Database links:

Entrez Gene: 1813 Human

Entrez Gene: 13489 Mouse

Entrez Gene: 24318 Rat

SwissProt: P14416 Human

SwissProt: P61168 Mouse

SwissProt: P61169 Rat



DAD2主要用于多態(tài)性與精神分裂癥方面的研究.
產(chǎn)品圖片
Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Rat Cerebrum tissue lysates Primary: Anti-DRD2 (bs-1008R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 51 kDa Observed band size: 50 kDa
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