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intestinal FABP Rabbit pAb (bs-0788R)  
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產(chǎn)品編號 bs-0788R
英文名稱 intestinal FABP Rabbit pAb
中文名稱 腸型脂肪酸結(jié)合蛋白抗體
別    名 FABP 2; FABP2; FABPI; Fatty acid binding protein 2 intestinal; Fatty acid binding protein intestinal; Fatty acid-binding protein; I-FABP; IFABP; Intestinal fatty acid binding protein 2; MGC133132; FABPI_HUMAN.  
研究領(lǐng)域 心血管  細胞生物  免疫學  生長因子和激素  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Pig,Chicken,Dog)
產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 15 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from IFABP: 45-132/132 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Intestinal FABP is an intestinal marker. It is expressed in the small intestine. Expression in the mucosal cells of the ileum extends from the midvillar region to the villus tips. It is thought to play a role in the intracellular transport of long chain fatty acids and their acyl CoA esters and may be involved in triglyceride rich lipoprotein synthesis.

Function:
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.

Similarity:
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Database links:

Entrez Gene: 2169 Human

Entrez Gene: 14079 Mouse

Entrez Gene: 25598 Rat

Omim: 134640 Human

SwissProt: P12104 Human

SwissProt: P55050 Mouse

SwissProt: P02693 Rat

Unigene: 282265 Human

Unigene: 28398 Mouse

Unigene: 91358 Rat



Fabp2脂肪酸結(jié)合蛋白-2,參與脂肪酸代謝、運輸、消化,該蛋白的異常增高使人的新陳代謝功能異常,影響人體消耗攝入的糖分,從而導致引發(fā)糖尿病的發(fā)生。FABP2多態(tài)性可能與2型糖尿病合并冠心病的胰島素抵抗相關(guān)聯(lián)。
產(chǎn)品圖片
Sample: Intestinal(Mouse) Lysate at 30ug; Primary: Anti-intestinal FABP (bs-0788R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution; Predicted band size: 15 kD Observed band size: 17 kD
Sample: Raji Cell Lysate at 30ug; Primary: Anti-intestinal FABP (bs-0788R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution; Predicted band size: 15 kD Observed band size: 17 kD
Tissue/cell: human colon carcinoma tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IFABP Polyclonal Antibody, Unconjugated(bs-0788R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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