亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線(xiàn):400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
51ⅴ精品国产91久久久久久,粉嫩的女同事24p
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Fibulin 1 Rabbit pAb (bs-0809R)  
訂購(gòu)熱線(xiàn):400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-0809R
英文名稱(chēng) Fibulin 1 Rabbit pAb
中文名稱(chēng) “衰老關(guān)鍵蛋白”抗體
別    名 Basement membrane protein 90; BM 90; FBLN; FBLN1; FIBL 1; FIBL1; Fibulin 1; FBLN1_HUMAN; FIBL-1; Fibulin-1.  
Specific References  (2)     |     bs-0809R has been referenced in 2 publications.
[IF=12.04] Angenendt, L., et al. "An atlas of bloodstream-accessible bone marrow proteins for site-directed therapy of acute myeloid leukemia." Leukemia(2017).  IHC-P ;  Human, Rat.  
[IF=4.175] Yi Hao. et al. Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer. Cancer Cell Int. 2021 Dec;21(1):1-13  WB,IF ;  Human.  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  免疫學(xué)  內(nèi)分泌病  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) (predicted: Human,Mouse,Rat,Pig,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 74 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Fibulin 1: 501-600/703 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Fibulin-1 is an extracellular matrix protein often associated with fibronectin (FN) in vivo. Fibulin-1 was found to have pronounced inhibitory effects on the cell attachment and spreading promoted by FN. Fibulin-1 was also found to inhibit the motility of a variety of cell types on FN substrata. For example, the FN-dependent haptotactic motility of breast carcinoma (MDA MB231) cells, epidermal carcinoma (A431), melanoma (A375 SM), rat pulmonary aortic smooth muscle cells (PAC1) and Chinese hamster ovary (CHO) cells was inhibited by the presence of fibulin-1 bound to FN-coated Boyden chamber membranes. Cells transfected to overproduce fibulin-1 displayed reduced velocity, distance of movement and persistence time on FN substrata. Similarly, the incorporation of fibulin-1 into FN-containing type I collagen gels inhibited the invasion of endocardial cushion mesenchymal cells migrating from cultured embryonic heart explants. By contrast, incorporation of fibulin-1 into collagen gels lacking FN had no effect on the migration of endocardial cushion cells.

Function:
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.

Subunit:
Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LAMA2, NID, ACAN, CSPG2 and type IV collagen. Interacts also with APP, NOV, FGB and HPV type 16, HPV type 18, HPV type 31 and BPV type 1 E6 proteins. Interacts with FBLN7.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells.

DISEASE:
Note=A chromosomal aberration involving FBLN1 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with C12orf2. Fibroblasts derived from a patient with synpolydactyly displayed alterations in the level of isoform D splice variant incorporated into the ECM and secreted into the conditioned culture medium. By contrast, the expression of isoform C was not perturbed in the patients fibroblasts. Furthermore, no aberrant polypeptides were detected in extracts of cultured patients fibroblasts. The translocation t(12;22) may result in haploinsufficiency of the isoform D splice variant, which could lead to the observed limb malformation.
Note=Elevated expression and altered processing of FBLN1 protein is associated with human breast cancer.

Similarity:
Belongs to the fibulin family.
Contains 3 anaphylatoxin-like domains.
Contains 9 EGF-like domains.

SWISS:
P23142

Gene ID:
2192

Database links:

Entrez Gene: 2192 Human

Entrez Gene: 14114 Mouse

Omim: 135820 Human

SwissProt: P23142 Human

SwissProt: Q08879 Mouse

Unigene: 24601 Human

Unigene: 593123 Human

Unigene: 297992 Mouse



版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
精品亚洲一区二区三区在线观看 | 精品国产麻豆免费人成网站 | 欧美一级久久久久久久久大 | 欧美精品视频在线观看视频 | 激情aa视频试看免费 | 久久国产精品免费观看 | 国产AV一区二区高潮久久 | 日韩欧无码一区二区三区免费不卡 | 无码乱码精品少妇一级内射 | 日韩美女乱淫试看屁视频网站 | 免费一级欧美片在线观 | 中文字幕无码乱码人妻系列 | 亚洲精品国产综合久久一线 | 性色AV一区二区三区V视界影院 | 波多野结衣av一区二区全免费观看 | 亚洲中文字幕无码一久久区 | 亚洲综合另类欧美久久久久精品 | 丁香婷婷色五月激情综合深爱 | 久久精品久久久精品美女 | 九九免费精品视频在这里 | 国产精品自产拍在线观看中文 | 亚洲国产欧美经典三级 | 狠狠躁18三区二区一区 | 国产精品久久久久久久久99热 | 女人一级毛片免费观看 | 国产成人AV在线播放影院 | 欧美日韩在线精品一区二区三区激情综合 | 国产精品一区在线麻豆 | 91精品一区二区三区在线观看 | 美女裸身露双奶头无遮挡免费视频 | 精人妻无码一区二区三区 | 免费无码片国产在线观看 | h嗯啊巨肉寝室男男bl | 96精产国品一二三产品区别 | 精品人妻中文字幕在线 | 亚洲精品白浆高清久久久久久 | 色综合久久88色综合天天 | 精品欧美一区二区三区久久久 | 人妻少妇精品无码专区二区 | 国产91在线精品国自产在线 | 色偷偷噜噜噜亚洲男人 |