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Calnexin Rabbit pAb (bs-1693R)  
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產(chǎn)品編號(hào) bs-1693R
英文名稱 Calnexin Rabbit pAb
中文名稱 鈣連蛋白抗體
別    名 Calnexin-ER membrane marker; CANX; Cell adhesion molecule with homology to l1cam precursor; CNX; D11Ertd153e; 1110069N15Rik; AI988026; FLJ26570; IP90; P90; Similar to calnexin; Major histocompatibility complex class I antigen-binding protein p88; CALX_HUM  
Specific References  (3)     |     bs-1693R has been referenced in 3 publications.
[IF=4] Correani, Virginia, et al. "Plasma membrane protein profiling in beta‐amyloid‐treated microglia cell line." Proteomics (2017).  WB ;  Mouse.  
[IF=3.21] Ming-Zhi Huang. et al. Exosomes from artesunate-treated bone marrow-derived mesenchymal stem cells transferring SNHG7 to promote osteogenesis via TAF15-RUNX2 pathway. REGEN MED. 2022 Oct 02  WB ;  Mouse, Human.  
[IF=2.989] Mignogna Giuseppina. et al. Rab11A Depletion in Microglia-Derived Extracellular Vesicle Proteome upon Beta-Amyloid Treatment. CELL BIOCHEM BIOPHYS. 2023 Mar;:1-11  WB ;  Mouse.  
研究領(lǐng)域 免疫學(xué)  染色質(zhì)和核信號(hào)  結(jié)合蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat (predicted: Rabbit,Cow,Chicken,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,Flow-Cyt=1μg /test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 65 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CANX: 501-592/592 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]

Function:
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.

Subunit:
Interacts with MAPK3/ERK1. Interacts with KCNH2. Associates with ribosomes. Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins.

Subcellular Location:
Endoplasmic reticulum membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Post-translational modifications:
Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity). br>Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins.

Similarity:
Belongs to the calreticulin family.

SWISS:
P27824

Gene ID:
821

Database links:

Entrez Gene: 821 Human

Entrez Gene: 12330 Mouse

Entrez Gene: 29144 Rat

Entrez Gene: 403908 Dog

Omim: 114217 Human

SwissProt: P24643 Dog

SwissProt: P27824 Human

SwissProt: P35564 Mouse

SwissProt: P35565 Rat

Unigene: 567968 Human

Unigene: 248827 Mouse

Unigene: 1762 Rat



內(nèi)質(zhì)網(wǎng)膜蛋白標(biāo)志物(ER membrane marker)
鈣連蛋白 calnexin 存在于內(nèi)質(zhì)網(wǎng)中,是內(nèi)質(zhì)網(wǎng)膜標(biāo)志物,屬于Ca2+的凝集素樣分子伴侶蛋白,可結(jié)合蛋白質(zhì)的寡糖鏈 ,防止蛋白質(zhì)彼此聚集和泛素化,避免折疊不完全的蛋白質(zhì)離開(kāi)內(nèi)質(zhì)網(wǎng)。
產(chǎn)品圖片
Sample: Lane 1: Mouse Testis tissue lysates Lane 2: Mouse Cerebrum tissue lysates Lane 3: Rat Testis tissue lysates Lane 4: Rat Cerebrum tissue lysates Lane 5: Human K562 cell lysates Lane 6: Human HeLa cell lysates Lane 7: Human HepG2 cell lysates Lane 8: Human U-2 OS cell lysates Lane 9: Human MCF-7 cell lysates Lane 10: Human A431 cell lysates Primary: Anti-Calnexin (bs-1693R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 65 kDa Observed band size: 78 kDa
Blank control:H9C2 Cells(blue). Primary Antibody: Rabbit Anti-CANX/FITC Conjugated antibody (bs-1693R/FITC), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/FITC(orange) ,used under the same conditions. Protocol The cells were washed twice with phosphate-buffered saline (PBS). The cells were incubated in 1 X PBS containing 0.5% BSA + 1 0% goat serum (15 min) to block non-specific protein-protein interactions followed by the antibody (bs-1693R/FITC, 1μg /1x10^6 cells) for 30 min on ice. Acquisition of 20,000 events was performed.
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