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IL-1R2 Rabbit pAb (bs-2595R)  
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產(chǎn)品編號(hào) bs-2595R
英文名稱 IL-1R2 Rabbit pAb
中文名稱 白介素1受體2抗體
別    名 IL1 Receptor II; IL-1R II; IL1 Receptor 2; interleukin-1 receptor type 2 precursor; IL1R2; CD121b; IL1RB; CD121; CD121 antigen-like family member B; CD121b; CD121B Antigen; CDW121B; IL-1R-2; IL-1R-beta; IL-1R2; IL-1RT-2; IL-1RT2; IL1R beta; Il1r-2; IL1R2;  
研究領(lǐng)域 免疫學(xué)  干細(xì)胞  淋巴細(xì)胞  b-淋巴細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Rat (predicted: Mouse,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1μg/test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 44 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-1R II: 301-398/398 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4(IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq].

Function:
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Subcellular Location:
Isoform Short: Secreted.
Isoform Long: Cell membrane; Single-pass type I membrane protein.

Post-translational modifications:
A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.

Similarity:
Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
P27930

Gene ID:
7850

Database links:

Entrez Gene: 7850 Human

Omim: 147811 Human

SwissProt: P27930 Human

Unigene: 25333 Human



IL-1RⅡ?qū)儆谛碌男盘?hào)受體家族Toll信號(hào)轉(zhuǎn)導(dǎo)通路蛋白,IL-1RⅡ在免疫和炎癥反應(yīng)的研究中占重要地位,是在很多感染 、炎癥性致病機(jī)制中起決定性作用的細(xì)胞因子,幾乎可作用于全身各種細(xì)胞,IL-1 與IL-1RⅡ的結(jié)合可導(dǎo)致大量與免疫反應(yīng)和炎癥相關(guān)基因的表達(dá) ,包括細(xì)胞因子、細(xì)胞因子受體、急性期反應(yīng)物、生長(zhǎng)因子、胞外基質(zhì)、粘附分子等。IL-1RⅡ/NF-κB信號(hào)通路是機(jī)體免疫反應(yīng)中十分重要的組成部分。
產(chǎn)品圖片
Sample: Lane 1: Human HepG2 cell lysates Lane 2: Human A549 cell lysates Primary: Anti-1R2 (bs-2595R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 44 kDa Observed band size: 68 kDa
Paraformaldehyde-fixed, paraffin embedded (Human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IL-1R2) Polyclonal Antibody, Unconjugated (bs-2595R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Blank control: RSC96 cells(blue). Primary Antibody: Rabbit Anti-IL-1R2 antibody(bs-2595R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG (orange) ,used under the same conditions. Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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