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Phospho-Cofilin (Ser3) Rabbit pAb (bs-3099R)  
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產(chǎn)品編號(hào) bs-3099R
英文名稱 Phospho-Cofilin (Ser3) Rabbit pAb
中文名稱 磷酸化絲切蛋白(Ser3)抗體
別    名 Cofilin(phospho-Ser3); Cofilin(phospho S3); 18 kDa phosphoprotein; CFL 1; CFL; CFL1; Cofilin 1; Cofilin 1 non muscle; Cofilin non muscle isoform; p18; COF1_HUMAN.  
Specific References  (3)     |     bs-3099R has been referenced in 3 publications.
[IF=4.014] Nuo Heng. et al. RhoA improves cryopreservation of rooster sperm through the Rho/RhoA-associated Kinase/cofilin pathway. POULTRY SCIENCE. 2022 Jul;:102051  WB ;  Chicken.  
[IF=2.894] Wufuer R et al. Downregulation of Rac1/PAK1/LIMK1/cofilin signaling pathway in colon cancer SW620 cells treated with Chlorin e6 photodynamic therapyPhotodiagnosis Photodyn Ther.2020 Dec 8;102143.  WB ;  Human.  
[IF=2.705] Xue Y et al. Methamphetamine?reduces?expressions?of?tight?junction?proteins,?rearranges?F-actincytoskeleton?and?increases?the?blood?brain?barrier?permeability?via?the?RhoA/ROCK-dependent pathway. Biochem Biophys Res Commun. 2019 Feb 5;509(2):395-401.  WB ;  Rat.  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  細(xì)胞粘附分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Mouse,Rat (predicted: Human,Pig,Sheep,Cow,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 18 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Cofilin around the phosphorylation site of Ser3: A(p-S)GV 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004].

Function:
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.

Subunit:
Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods.

Subcellular Location:
Nucleus matrix. Cytoplasm, cytoskeleton.

Tissue Specificity:
Widely distributed in various tissues.

Post-translational modifications:
Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells. Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.

Similarity:
Belongs to the actin-binding proteins ADF family.
Contains 1 ADF-H domain.

SWISS:
P23528

Gene ID:
1072

Database links:

Entrez Gene: 1072 Human

Entrez Gene: 534553 Cow

Entrez Gene: 12631 Mouse

Entrez Gene: 445532 Pig

Entrez Gene: 29271 Rat

Entrez Gene: 494432 Sheep

Omim: 601442 Human

SwissProt: Q5E9F7 Cow

SwissProt: P23528 Human

SwissProt: P18760 Mouse

SwissProt: P10668 Pig

SwissProt: P45592 Rat

SwissProt: Q6B7M7 Sheep

Unigene: 52428 Cow

Unigene: 170622 Human

Unigene: 329655 Mouse

Unigene: 11675 Rat

Unigene: 13212 Sheep



絲切蛋白(cofilin)是細(xì)胞骨架塑形的重要調(diào)節(jié)因素,其主要功能是分解肌動(dòng)蛋白微絲和增加肌動(dòng)蛋白單體從肌動(dòng)蛋白微絲的末端解離的速度,從而促進(jìn)肌動(dòng)蛋白微絲的循環(huán),是目前為止已發(fā)現(xiàn)的肌動(dòng)蛋白結(jié)合蛋白家族中唯一能夠改變肌動(dòng)蛋白微絲扭曲結(jié)構(gòu)的蛋白.
產(chǎn)品圖片
Sample: Cerebrum (Mouse) Lysate at 40 ug Primary: Anti-Phospho-Cofilin (Ser3) (bs-3099R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 18 kD Observed band size: 18 kD
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Phospho-Cofilin (Ser3)) Polyclonal Antibody, Unconjugated (bs-3099R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Phospho-Cofilin (Ser3)) Polyclonal Antibody, Unconjugated (bs-3099R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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