亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
91人人人玩人人妻精品99,老色皮永久免费网站
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
APS Rabbit pAb (bs-2731R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-2731R
英文名稱 APS Rabbit pAb
中文名稱 APS抗體
別    名 APS; Adaptor protein with pleckstrin homology and src homology 2 domains; SH2 and PH domain containing adapter protein APS; SH2B2_HUMAN; SH2B adapter protein 2; Adapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APS.  
研究領域 細胞生物  免疫學  神經(jīng)生物學  信號轉(zhuǎn)導  細胞凋亡  激酶和磷酸酶  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Chicken,Dog,Horse)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 68 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human APS: 401-500/632 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

Function:
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.

Subunit:
Homodimer. Interacts with KIT/c-KIT, SHC1, EPOR, PDGFR, VAV1 and VAV3. Interacts (via N-terminal region) with SHC1. Interacts (via the phosphorylated C-terminus) with GRB2. Interacts (via its SH2 domain) with EPOR, INSR and KIT. Interacts with GRB2 after B-cell antigen receptor stimulation. Interacts (via PH domain) with VAV3. Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated); after stimulation of the receptor by its extracellular ligand and subsequent autophosphorylation of the receptor. Binds INSR, GRB2, ASB6 and CAP. Insulin stimulation leads to dissociation of CAP. Binds CBS only when SH2B2/APS has become phosphorylated. INSR binding does not depend on the phosphorylation of SH2B2/APS.

Subcellular Location:
Cytoplasm. Cell membrane. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.

Tissue Specificity:
Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines.

Post-translational modifications:
Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex.

Similarity:
Belongs to the SH2B adapter family.
Contains 1 PH domain.
Contains 1 SH2 domain.

SWISS:
O14492

Gene ID:
10603

Database links:

Entrez Gene: 10603 Human

Omim: 605300 Human

SwissProt: O14492 Human

Unigene: 371366 Human



版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
在线永久看片免费的视频 | 蜜桃视频无码区在线观看 | 少妇高清精品毛片在线视频 | 中文字幕无码精品久久久 | 国产AV国片精品一区二区 | 野花高清在线观看免费 | 日韩视频在线精品视频免费观看 | 精品欧美一区二区三区久久久 | 国产黄A真人一级无码毛片一区二区三区 | 日韩精品无码熟人妻视频 | 免费无码又黄又爽又刺激 | 怡红院日本一道日本久久 | 久久久久久久国产免费看 | 寡妇高潮一级毛片免费看 | 国产一级精品免费看高清99 | 欧美性猛交XXXX乱大交极品 | 欧美一区二区三区不卡免费 | 国产精品美女自在线观看免费 | 真人做爰到高潮视频18禁 | 人人揉人人捏人人爽五月天 | 好舒服好粗好硬免费视频 | 久久久久久久久久国产精品免费 | 中文字幕在线成人免费看 | www.xxxx.日本| 屁屁国产第1页草草影院 | 国产成人综合亚洲欧美日韩 | 色欲午夜无码久久久久久 | 贵州美女一级纯黄大片 | 欧美日韩视频在线视频二区 | 好男人好资源官网在线观看 | 国产内射爽爽大片视频社区在线 | 欧美freesex黑人又粗又大 | 欧美高清免费精品国产自 | 国产精一品亚洲二区在线播放 | 国产人成无码视频在线1000 | 精品国产一区二区三区AV性色 | 狂躁美女大BBBBBB视频1 | 黄录像欧美片在线观看 | 国产精品v欧美精品v日韩精品 | 国产精品久久综合桃花网 | 亚洲日本香蕉观看观视频 |