亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
中文字幕丰满乱孑伦无码专区 ,中文在线а√天堂官网,男女一级毛片免费视频看
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Phospho-MKK3(Ser218) + MKK6(Ser207) Rabbit pAb (bs-3274R)  
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)

產(chǎn)品編號(hào) bs-3274R
英文名稱 Phospho-MKK3(Ser218) + MKK6(Ser207) Rabbit pAb
中文名稱 磷酸化絲裂原活化蛋白激酶MKK3/6抗體
別    名 MKK3(phospho-Ser218); MAP Kinase Kinase 3; Dual specificity mitogen activated protein kinase kinase 3; ERK kinase 3; MAP kinase kinase 3; MAP2K 3; MAPK ERK kinase 3; MAPK kinase 3; MAPKK 3; MAPKK3; MEK 3; MEK3; Mitogen activated protein kinase kinase 3; MKK 3; MKK3; mMKK 3b; mMKK3b; MPK 3; PRKMK 3; PRKMK3; Protein kinase mitogen activated kinase 3; SKK2; zMKK 3; MP2K3_HUMAN; MP2K6_HUMAN  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  細(xì)胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Human,Mouse,Rat (predicted: Rabbit,Pig,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human MKK3 around the phosphorylation site of Ser218: VD(p-S)VA 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.

Function:
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.

Subunit:
Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with ARRB1. Interacts with Yersinia yopJ.

Tissue Specificity:
Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Post-translational modifications:
Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Phosphorylated by TAOK2.
Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.

DISEASE:
Note=Defects in MAP2K3 may be involved in colon cancer.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Contains 1 protein kinase domain.

SWISS:
P46734

Gene ID:
5606

Database links:

Entrez Gene: 5606?Human

Entrez Gene: 26397?Mouse

Entrez Gene: 303200?Rat

Omim: 602315?Human

SwissProt: P46734?Human

SwissProt: O09110?Mouse

Unigene: 514012?Human

Unigene: 18494?Mouse

Unigene: 100064?Rat



產(chǎn)品圖片
Sample: Muscle(Rat) Lysate at 40 ug Primary: Anti-Phospho-MKK3(Ser218) + MKK6(Ser207) (bs-3274R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 40 kD
Sample: Muscle (Mouse) Lysate at 40 ug Primary: Anti-Phospho-MKK3(Ser218) + MKK6(Ser207) (bs-3274R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 40 kD
Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (Phospho-MKK3(Ser218) + MKK6(Ser207)) Polyclonal Antibody, Unconjugated (bs-3274R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human lung carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (Phospho-MKK3(Ser218) + MKK6(Ser207)) Polyclonal Antibody, Unconjugated (bs-3274R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Phospho-MKK3(Ser218) + MKK6(Ser207)) Polyclonal Antibody, Unconjugated (bs-3274R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
九九热线有精品视频99 | 亚洲精品无码不卡在线播HE | 亚洲欧美日本韩国 | 高清有码国产一区二区 | 第九色区av天堂 | 爱啪网亚洲第一福利网站 | 国产最新一区二区三区天堂 | 国产精品xxxav免费视频 | 91亚洲一区二区三区 | 欧美成人精品欧美一级乱黄 | 丁香六月久久婷婷开心 | 国产精品密蕾丝视频下载 | 日韩欧美一区二区三区在线 | 男女后进式猛烈XX00动态图片 | 亚洲AV无码一区二区三区乱子伦 | 亚洲一级AⅤ无码毛片不卡 亚洲精品白浆高清久久久久久 | 日本欧美一区二区三区片 | 一级毛片视频免费 | 放荡的小峓子2中文字幕 | 999国内精品永久免费视频 | 亚洲日韩一区精品射精 | 久久av无码av高潮av喷吹捆绑 | 亚洲精品无码不卡在线播HE | 国产在线一区二区三区四区 | 中文字幕日韩人妻在线乱码 | 国产精品免费一区二区三区四区 | 亚洲日韩国产AV无码无码精品 | 极品尤物喷水爆白浆呻吟小说 | 国产精品免费小视频 | AV午夜午夜快憣免费观看 | 99国精品午夜福利视频不卡 | 久久天天躁狠狠躁夜夜97 | 一个人看的免费视频大全在线观看 | 亚洲日韩精品国产3区 | 成人无码WWW免费视频网站 | 久久成人国产精品麻豆 | 国内精品久久久久影院久久久91 | 色偷偷偷久久伊人大杳蕉 | 午夜国产精品a小视频 | 中文在线中文资源 | 欧美日韩国产色综合一二三四 |