亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
日韩AV毛片精品久久久,中国黄色毛片大片
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Nuclear Matrix Protein p84 Rabbit pAb (bs-2448R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-2448R
英文名稱 Nuclear Matrix Protein p84 Rabbit pAb
中文名稱 核基質(zhì)p84蛋白抗體
別    名 Death domain containing protein p84N5; HPR 1; HPR1; hTREX84; Nuclear matrix protein p84; P84; P84N5; Tho 1; THO complex 1; THO complex subunit 1; Tho1; THOC 1; THOC1; THOC1_HUMAN.  
Specific References  (1)     |     bs-2448R has been referenced in 1 publications.
[IF=6.741] Hui-Wen Chiu. et al. Cinacalcet improves bone parameters through regulation of osteoclast endoplasmic reticulum stress, autophagy, and apoptotic pathways in chronic kidney disease-mineral and bone disorder. 2021 Oct 11  WB ;  Mouse.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  發(fā)育生物學(xué)  染色質(zhì)和核信號  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 72 kDa
檢測分子量
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HPR1/Nuclear Matrix Protein p84: 221-320/657 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This protein is part of the THO complex (THOC). The THO complex is recruited to transcribed genes and travels with the RNA polymerase during elongation. It may physically link proteins that function in transcription and in RNA export and RNA processing.

Function:
Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4.
Regulates transcriptional elongation of a subset of genes. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.

Subunit:
Component of the THO complex, which is composed of THOC1, THOC2, THOC5, THOC6 and THOC7. Together with THOC3, ALYREF/THOC4 and DDX39B, THO forms the transcription/export (TREX) complex. Binds to the hypophosphorylated form of RB1. Interacts with THOC2, DDX39B and RNA polymerase II.

Subcellular Location:
Isoform 1: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution. Isoform 2: Cytoplasm.

Tissue Specificity:
Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression.

Post-translational modifications:
Expression is altered specifically during apoptosis and is accompanied by the appearance of novel forms with smaller apparent molecular mass.

Similarity:
Contains 1 death domain.

SWISS:
Q96FV9

Gene ID:
9984

Database links:

Entrez Gene: 9984 Human

Entrez Gene: 225160 Mouse

Entrez Gene: 291797 Rat

Omim: 606930 Human

SwissProt: Q96FV9 Human

SwissProt: Q8R3N6 Mouse

SwissProt: P59924 Rat

Unigene: 712543 Human

Unigene: 219648 Mouse

Unigene: 127881 Rat



版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产精品反差婊在线观看 | 顶级欧美做受XXX000 | 精品乱码久久久久久中文字幕 | 国产精品久久免费视频 | 精品无码国产AV一区二区性色 | 最新黄色网址在线观看 | 人人妻人人澡人人爽国产一区 | 狠狠躁夜夜躁人人爽天天69 | GOGO人体无码一区二区 | 久久午夜一区二区 | 白丝初音未来被调教出奶水 | 日韩精品区一区二区三VR | 激情爆乳一区二区三区 | 老熟妇一区二区三区啪啪 | 精品一区二区三区免费观看 | 99久久这里只精品国产免费 | 久久国产精品99精品国产 | 亚洲人AV永久一区二区三区久久 | 青春禁区在线观看免费 | 中文字日产幕码三区的做法大全 | 99无码熟妇丰满人妻啪啪 | 无码A级毛片日韩精品 | 亚洲精品蜜夜内射 | 日韩熟妇啪啪无码视频 | 国产在线观看免费一级 | 久久久久久久精品一区二区三区 | 日韩Av无码久久一区二区 | 浪潮AV色综合久久天堂 | 国产精品户露AV在线户外直播 | 国产精品视频一区二区三区 | 又污又黄又无遮挡网站 | 精品国产一区二区三区久久影院 | 欧美日韩视频一区二区三区 | 亚洲成人电影在线观看精品国产 | 久久久久久国产精品日本 | 第一天破了英语课代表的处 | 风流少妇又紧又爽又丰满 | 乱欧人与牲口杂交暴力狂 | 亚洲AV无码一区二区三区性色 | 黄色网站免费在线观看 | 国产精品网站在线观看免费传媒 |