| 產(chǎn)品編號(hào) | bs-2210P |
| 英文名稱(chēng) | phospho-p38 MAPK (Thr180 + Tyr182) Peptide |
| 中文名稱(chēng) | 磷酸化絲裂原活化蛋白激酶p38多肽 |
| 別 名 | p38 (phospho T180 + Y182); p-p38 (phospho T180 + Y182); p38 (phospho T180/Y182); CSAID Binding Protein 1; CSAID binding protein; CSAID-binding protein; Csaids binding protein; CSBP 1; CSBP 2; CSBP; CSBP1; CSBP2; CSPB 1; CSPB1; Cytokine suppressive anti in |
| 理論分子量 | kDa |
| 檢測(cè)分子量 | |
| 性 狀 | Lyophilized |
| 純化方法 | 1 |
| 活性 | Not tested |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
bs-2210P is a synthesised phosphopeptide derived from human p38 MAPK around the phosphorylation site of Thr180/Tyr182:EM(p-T)G(p-Y)VA. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases(MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
