亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
国产精品国产三级国产an,亚洲日韩在线男人视频网站
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
SIRT6 Rabbit pAb (bs-4174R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-4174R
英文名稱 SIRT6 Rabbit pAb
中文名稱 沉默調(diào)節(jié)相關蛋白6抗體
別    名 NAD-dependent protein deacylase sirtuin-6; SIR2L6; EC:2.3.1.-; NAD-dependent protein deacetylase sirtuin-6; Protein mono-ADP-ribosyltransferase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2-like protein 6; SIR6_HUMAN;  
研究領域 腫瘤  心血管  染色質(zhì)和核信號  信號轉(zhuǎn)導  細胞凋亡  新陳代謝  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat)
產(chǎn)品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIRT6: 121-220/355 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Function:
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

Subunit:
Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.

Subcellular Location:
Nucleus, nucleoplasm.

Similarity:
Belongs to the sirtuin family. Class IV subfamily.
Contains 1 deacetylase sirtuin-type domain.

SWISS:
Q8N6T7

Gene ID:
51548

Database links:

Entrez Gene: 51548 Human

Entrez Gene: 50721 Mouse

Entrez Gene: 299638 Rat

SwissProt: Q8N6T7 Human

SwissProt: P59941 Mouse



SIRT6是一種酶,能夠從組蛋白的一個特定位點上移走稱之為乙?;M的化學物質(zhì)。組蛋白對調(diào)控基因表達非常重要,而從組蛋白中移除乙酰基組就會“關閉”某些基因表達。 SIRT6蛋白與NF-kappaB(NF-kB)一同,可以調(diào)節(jié)凋亡、炎癥和新陳代謝相關基因的作用。當減少SIRT6時,NF-kappaB變得過度活躍,開啟同衰老相關的基因。
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
丝袜另类在线观看网站 | 国产精品99久久久久久WWW | 丰满少妇被猛烈进入毛片 | 无码一区二区三区亚洲人妻 | 9191精品国产日本欧美 | 无码精品A∨在线观看中文 欧美激情视频在线观看一区二区三区 | 日韩亚洲人成在线 | 免费黃色三級片在线观看18 | 免费伦费一区二区三区四区 | 久久另类精品欧美日韩高清精品不卡 | 久久久久久久国产免费看 | 国产成+人欧美+综合在线观看 | 亚洲精品无码不卡在线播HE | 日本人爽p大片免费看 | 榴莲视频在线看一日韩 | 国产成人综合亚洲欧美在线观看 | 最近中文字幕mv免费视频 | 国产精品亚洲综合五月天 | 亚洲春色AV无码专区 | 日韩免费一区二区三区在线 | 免费一级A片毛毛片在线播放99 | WWW久久只有这里有精品 | 国产一区二区高清 | 久久国产精品久久国产精品 | 成人免费毛片AAAAAA片 | 在线观看黄网视频免费播放 | 亚洲天天做日日做天天谢日日欢 | 久久久精品2019免费观看 | 亚洲欧美日韩中文加勒比 | 国产一区二区在线免费观看 | 国产日韩欧美一区二区综合区 | 国产精华液一级毛片久久久久久久女人18 | 欧美一级久久久久久久大片 | 国产做a爱一级毛片久久 | 美女赤裸裸一丝不遮的图片动图 | 国产午夜手机精彩视频 | 国产精品美女免费视频观看 | 国产精品久久久久久久9999 | 日本黄色成年人免费观看 | 日韩一区二区三区视频在线观看 | 4455永久在线毛片观看 |