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CD16 Rabbit pAb (bs-6028R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產(chǎn)品編號 bs-6028R
英文名稱 CD16 Rabbit pAb
中文名稱 FC段γ受體3/免疫球蛋白G Fc段受體III抗體
別    名 FCG3A_HUMAN; Low affinity immunoglobulin gamma Fc region receptor III-A; CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: D16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3.  
Specific References  (12)     |     bs-6028R has been referenced in 12 publications.
[IF=15.304] Yao Lei. et al. Phytochemical natural killer cells reprogram tumor microenvironment for potent immunotherapy of solid tumors. BIOMATERIALS. 2022 Jun;:121635  WB, IF, FC ;  Mouse.  
[IF=11.492] Laura Lopez-Sanz. et al. Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development. Clin Transl Med. 2021 Jul;11(7):e463  IHC ;  Human.  
[IF=6.147] Weishi Liang. et al. The Role of Microglia/Macrophages Activation and TLR4/NF-κB/MAPK Pathway in Distraction Spinal Cord Injury-Induced Inflammation. FRONT CELL NEUROSCI. 2022; 16: 926453  IF ;  Pig.  
[IF=5.732] Sun Wei. et al. The effects of maternal anti-alpha-enolase antibody expression on the brain development in offspring. CLIN EXP IMMUNOL. 2022 Sep;:  IF ;  Mouse.  
[IF=5.195] Shan Luo. et al. Application of omics technology to investigate the mechanism underlying the role of San Hua Tang in regulating microglia polarization and blood-brain barrier protection following ischemic stroke. J ETHNOPHARMACOL. 2023 May;:116640  WB ;  Rat.  
[IF=4.657] He, Xiaojing. et al. Inhibition of PD-1 Alters the SHP1/2-PI3K/Akt Axis to Decrease M1 Polarization of Alveolar Macrophages in Lung Ischemia–Reperfusion Injury. INFLAMMATION. 2022 Nov;:1-16  IHC ;  Rat.  
[IF=4.486] Yang Jiao. et al. Inhibition of microglial receptor‐interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke. J Cell Mol Med. 2020 Nov;24(21):12585-12598  WB,IF ;  Mouse.  
[IF=3.943] Yihan Lu? et al. Experimental evidence for alpha enolase as one potential autoantigen in the pathogenesis of both autoimmune thyroiditis and its related encephalopathy. Int Immunopharmacol. 2020 Aug;85:106563.  IF ;  Mouse.  
[IF=3.59] Hanshu Zhao. et al. PHLDA1 Blockade Alleviates Cerebral Ischemia/Reperfusion Injury by Affecting Microglial M1/M2 Polarization and NLRP3 Inflammasome Activation. Neuroscience. 2022 Jan;:  IF ;  Mouse.  
[IF=3.37] Jing Liet al. hUC-MSCs ameliorated CUMS-induced depression by modulating complement C3 signaling-mediated microglial polarization during astrocyte-microglia crosstalk. Brain Res Bull . 2020 Oct;163:109-119.  IHC ;  mouse.  
[IF=3.041] An G et al. Effects of CCL5 on the biological behavior of breast cancer and the mechanisms of its interaction with tumor?associated macrophages. Oncol Rep.?2019 Dec;42(6):2499-2511.  IHC-P ;  Human.  
[IF=2.38] Ding, Peng, et al. "Expression of Tumor-Associated Macrophage in Progression of Human Glioma." Cell Biochemistry and Biophysics (2014): 1-7.  IHC-P ;  Human.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  干細(xì)胞  細(xì)胞表面分子  細(xì)胞類型標(biāo)志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 27 kDa
檢測分子量
細(xì)胞定位 細(xì)胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IGFR3/CD16: 131-230/254 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]

Function:
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Subunit:
Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1.

Subcellular Location:
Cell membrane. Secreted. Exists also as a soluble receptor.

Tissue Specificity:
Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.

Post-translational modifications:
Glycosylated. Contains high mannose- and complex-type oligosaccharides.
The soluble form is produced by a proteolytic cleavage. [MISCELLANEOUS] Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the 'Ser-203' in III-B determines the GPI-anchoring.

Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
P08637

Gene ID:
2214

Database links:

Entrez Gene: 2214 Human

Entrez Gene: 14131 Mouse

Entrez Gene: 304966 Rat

Omim: 146740 Human

SwissProt: P08637 Human

SwissProt: P08508 Mouse

SwissProt: P27645 Rat

Unigene: 372679 Human



產(chǎn)品圖片
Sample: Lane 1: Thymus (Rat) Lysate at 40 ug Lane 2: Lymph node (Mouse) Lysate at 40 ug Primary: Anti-CD16 (bs-6028R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 60 kD
Sample: Raw264.7(Mouse) Cell Lysate at 30 ug Primary: Anti- CD16 (bs-6028R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 27 kD Observed band size: 50 kD
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