亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
欧美一级高清AAA片免费观看 ,日本三级电影在线看
首頁 > 產品中心 > 一抗 > 產品信息
TCF3 Rabbit pAb (bs-6065R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-6065R
英文名稱 TCF3 Rabbit pAb
中文名稱 轉錄因子3抗體
別    名 TFE2_HUMAN; Transcription factor E2-alpha; BHLHB21; E2A; ITF1; E47; p75; AGM8; VDIR; AGM8A; AGM8B; TCF-3; bHLHb21Class B basic helix-loop-helix protein 21(bHLHb21); Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription factor 3(TCF-3); Transcription factor ITF-1;  
研究領域 染色質和核信號  信號轉導  干細胞  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse,Rat (predicted: Cow,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 67 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TCF3/E2A: 301-400/654 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

Function:
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.

Subunit:
Forms a heterodimer with ASH1 and TWIST2. Isoform E12 interacts with RALGAPA1 and FIGLA. Efficient DNA binding requires dimerization with another bHLH protein. Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with NEUROD2, PTF1A and TGFB1I1 (By similarity). Homodimer. Heterodimer. Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Interacts with EP300 and UBE2I.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated following NGF stimulation (By similarity).

DISEASE:
Note=Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1. TCF3-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family. Translocation t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT.

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.

SWISS:
P15923

Gene ID:
6929

Database links:

Entrez Gene: 6929 Human

Entrez Gene: 21423 Mouse

Entrez Gene: 171046 Rat

SwissProt: P15923 Human

SwissProt: P15806 Mouse

SwissProt: P21677 Rat



產品圖片
Sample: A549 Cell (Human) Lysate at 40 ug Raji Cell (Human) Lysate at 40 ug Primary: Anti-TCF3 (bs-6065R) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (bs-0295G-HRP) at 1/5000 dilution Predicted band size: 67 kD Observed band size: 67 kD
Sample: Lane 1: Human Jurkat cell lysates Lane 2: Human K562 cell lysates Primary: Anti-TCF3 (bs-6065R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 67 kDa Observed band size: 67 kDa
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TCF3) Polyclonal Antibody, Unconjugated (bs-6065R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-TCF3 Polyclonal Antibody, Unconjugated(bs-6065R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
好爽又高潮了毛片免费下载 | 日本韩国欧美一区 | 91情国产l精品国产亚洲区 | 国产欧美精品区一区二区三区 | 国产欧美日韩专区发布 | 人妻妺妺窝人体色WWW聚色窝 | 色婷婷综合激情中文在线 | 两个人看的www视频中文字幕 | q2002午夜我的老师 | 加勒比色综合久久久久久久久 | 国产在线观看免费一级 | 亚洲高清在线精品一区 | 特级做A爰片毛片免费看108 | 在线观看黄色视频网站 | 女人让男人捅30分钟 | 日韩欧美一区二区三区在线 | 99精品一级欧美片免费播放 | 欧美亚洲清纯国产综合图区 | 国产综合精品久久久久成人影 | 正在播放国产精品 | 久久婷婷五月综合色精品 | 日韩中文字幕免费的视频在线看网站 | 两口子交换真实刺激高潮 | 夜夜添无码试看一区二区三区 | 国产91在线视频观看 | 国精品午夜福利视频不卡麻豆 | h嗯啊巨肉寝室男男bl | 亚洲精品日韩片无码中文字幕 | 亚洲国产在线精品一区在 | 亚洲女精品一区二区三区 | 久久99精品久久久久久园产越南 | 2020精品国产自在现线官网 | 欧美一级又粗又大真做 | 男人的天堂免费观看视频 | 欧美性猛交aaaaa免费看 | 久久久久久久99精品免费观看 | 久久久久久国产a免费观看黄色大片 | 久久久无码人妻精品无码 | 欧美精品中文字幕亚洲专区 | 顶级少妇AAAAABBBBB片 | 男女后进式猛烈XX00动态图片 |