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DCAF6 Rabbit pAb (bs-6210R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6210R
英文名稱 DCAF6 Rabbit pAb
中文名稱 雄激素受體復(fù)合物相關(guān)蛋白/核受體相互作用蛋白抗體
別    名 DDB1-and CUL4-associated factor 6; Androgen receptor complex associated protein; ARCAP; IQ motif and WD repeats 1; IQWD1v MSTP055; Nuclear receptor interaction protein; RP4 745I14.1; NRIP; DCAF6_HUMAN.  
研究領(lǐng)域 腫瘤  心血管  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 96 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NRIP: 245-350/860 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 WD-repeat proteins are a large family of eukaryotic proteins coordinating multi-protein complex assemblies. Their role has been implicated in multiple cellular processes including signal transduction, transcriptional regulation, cell cycle control and apoptosis. NRIP is a novel 860a.a nuclear protein consisting of seven conserved WD40 domains and one NLS motif. It binds to androgen and glucocorticoid receptors and up-regulates their transcriptional activity, thereby functioning as a nuclear receptor co-activator. Role of NRIP has been implicated in cell growth and also in cervical and prostrate cancer, thus indicating a potential therapeutic intervention. Northern Blot analysis detects a high expression of NRIP in skeletal muscle and testis and low expression in heart, prostrate and adrenal gland.

Function:
Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Subunit:
Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A and CUL4B.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland.

Similarity:
Contains 1 IQ domain.
Contains 7 WD repeats.

SWISS:
Q58WW2

Gene ID:
55827

Database links:

Entrez Gene: 55827 Human

Entrez Gene: 74106 Mouse

Entrez Gene: 289181 Rat

Omim: 610494 Human

SwissProt: Q58WW2 Human

SwissProt: Q9DC22 Mouse

Unigene: 435741 Human

Unigene: 227605 Mouse



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