亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产乱妇乱子视频在播放,亚洲高清一区二区三区电影 ,超级乱淫片午夜电影网99
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
Exportin 1 Rabbit pAb (bs-2953R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產(chǎn)品編號 bs-2953R
英文名稱 Exportin 1 Rabbit pAb
中文名稱 染色體區(qū)域穩(wěn)定蛋白/核輸出蛋白1/染色體區(qū)域穩(wěn)定必需蛋白抗體
別    名 Chromosome region maintenance 1 protein homolog; CRM 1; CRM1; CRM1 homolog; DKFZp686B1823; Exp 1; Exp-1; Exp1; Exportin 1; Exportin1; Exportin-1; XPO 1; XPO1; XPO1_HUMAN.  
研究領(lǐng)域 細(xì)胞生物  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat (predicted: Pig)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 118 kDa
檢測分子量
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Exportin 1: 501-600/1071 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 CRM1 (chromosome region maintenance 1 protein homolog) mediates the nuclear export of cellular proteins (cargoes) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, CRM1 binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The direction of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. CRM1 also mediates the nuclear export of the Rev protein of HIV-1 and Rex protein of HTLV-1. It is involved in Rex dimerization, U3 snoRNA transport from Cajal bodies to nucleoli.
CRM1 is also involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. CRM1 is also involved in the regulation NFAT and AP-1.


Subunit:
Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 and m7G-capped RNA (By similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 and TERT. Also found in complex with several viral proteins involved in RNAs' nuclear export like HIV-1 Rev and HTLV-1 Rex. Interacts presumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'.

Subcellular Location:
Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.

Tissue Specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.

Similarity:
Belongs to the exportin family.
Contains 10 HEAT repeats.
Contains 1 importin N-terminal domain.

SWISS:
O14980

Gene ID:
7514

Database links:

Entrez Gene: 7514 Human

Entrez Gene: 103573 Mouse

Entrez Gene: 85252 Rat

Omim: 602559 Human

SwissProt: O14980 Human

SwissProt: Q6P5F9 Mouse

SwissProt: Q80U96 Rat

Unigene: 370770 Human

Unigene: 217547 Mouse

Unigene: 34087 Rat



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Exportin 1) Polyclonal Antibody, Unconjugated (bs-2953R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Exportin 1) Polyclonal Antibody, Unconjugated (bs-2953R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Exportin 1/CRM1 Polyclonal Antibody, Unconjugated(bs-2953R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Exportin 1/CRM1 Polyclonal Antibody, Unconjugated(bs-2953R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
久久夜色精品国产噜噜亚洲av | 免费一级做a爰片久久毛片潮喷 | 国产精品青青在线麻豆 | 国产a级三级三级成人国产一级婬片 | 午夜在线观看视频免费成人 | 欧美一级特黄AAAAAAAA片在线看 | 宅男午夜大片又黄又爽大片 | 精品1区2区3区产品乱码 | 日韩丰满少妇无码内射 | 国产精品久久久久无毒 | 超碰97久久久久久久久久久 | 国产欧美日韩综合一区在线播放 | 麻豆果冻传媒新剧国产杜鹃 | 久久97精品久久久久久久看片 | 亚洲中文字幕无码中文字无摸 | 在线成人免费观看国产精品 | 一级a性色生活片久久无 | 黄色网站在线观看视频 | 欧美最猛性xxxxx亚洲精品 | 亚洲天天做日日做天天谢日日欢 | 欧美搡BBBBB搡BBBBB | 91在线视频免费播放 | 91精品久久久久久久久久 | 农村女人一级毛片20岁的毛片 | 最新亚洲中文字幕一区在线 | 伊人久久综合精品无码A∨专区 | 狼人香蕉香蕉在线28 | 日韩一区二区三区四区区区 | 少妇高清精品毛片在线视频 | 毛片线看免费观看 | 国产亚洲精品中文带字幕21页 | 国产未发育呦交视频 | 欧美日韩无套内射另类 | 色狠狠一区二区三区熟女91 | 婷婷国产精品久久久久精 | 囯产精品一品二区三区 | 日本一级A片在线观看播放 久久精品中文字幕第一页国产精品 | 国产精品久久久久久久人热 | 久久亚洲精品中文字幕 | 欧美97色伦欧美一区二区日韩 | 91久久综合精品国产丝袜长腿 |