| 產(chǎn)品編號 | bs-7506R |
| 英文名稱 | SMOC2 Rabbit pAb |
| 中文名稱 | 分泌模塊化鈣結(jié)合蛋白2/平滑肌相關(guān)蛋白2抗體 |
| 別 名 | Secreted modular calcium binding protein 2; SMAP 2; SMAP2; SMOC 2; Smooth muscle associated protein 2; SPARC related modular calcium binding 2; dJ421D16.1; MST117; MSTP117; bA270C4A.1; bA37D8.1; dJ421D16.1(novel thyroglobulin type 1 repeat containing prot |
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Specific References (1) | bs-7506R has been referenced in 1 publications.
[IF=4.147] Feng Long. et al. A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects. Bone. 2021 Jan;142:115686 WB ; Human.
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| 研究領(lǐng)域 | 心血管 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 生長因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 血管內(nèi)皮細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 47 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SMOC2: 311-410/446 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
SMOC 2 (Secreted modular calcium binding protein 2) is a secreted modular protein containing an EF hand calcium binding domain homologous to that in BM40. It consists of two thyroglobulin like domains, a follistatin like domain and a novel domain found only in the homologous SMOC 1. SMOC 1 and 2 form a separate group within the BM40 family. SMOC 2 is a glycoprotein with a calcium dependent conformation. SMOC 2 contains 2 EF hand calcium binding domains, 1 Kazal like domain and 2 thyroglobulin type I domains. Function: Promotes matrix assembly and cell adhesiveness. Can stimulate endothelial cell proliferation, migration, as well as angiogenesis. Subunit: Binds various proteins from the extracellular matrix. Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane. DISEASE: Defects in SMOC2 are the cause of dentin dysplasia typ1 (DTDP1) [MIM:125400]. A dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent. Similarity: Contains 2 EF-hand domains. Contains 1 Kazal-like domain. Contains 2 thyroglobulin type-1 domains. SWISS: Q9H3U7 Gene ID: 64094 Database links: Entrez Gene: 64094 Human Entrez Gene: 64074 Mouse Omim: 607223 Human SwissProt: Q9H3U7 Human SwissProt: Q8CD91 Mouse Unigene: 487200 Human Unigene: 30162 Mouse |
