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MSR1 Rabbit pAb (bs-6763R)  
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50ul/1180.00元
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產(chǎn)品編號 bs-6763R
英文名稱 MSR1 Rabbit pAb
中文名稱 巨噬細(xì)胞清道夫受體1抗體
別    名 CD204; SP-A; CD204 antigen; Macrophage acetylated LDL receptor I and II; Macrophage scavenger receptor 1; Macrophage Scavenger Receptor I; Macrophage scavenger receptor type III; Macrophage scavenger receptor types I and II; Msr 1; MSR1; MSRE_HUMAN; phSR1; phSR2; SCARA 1; SCARA1; Scavenger receptor class A member 1; Scavenger receptor type A; Scvr; SR A; SRA.  
Specific References  (9)     |     bs-6763R has been referenced in 9 publications.
[IF=8.097] Ye M et al. SR-A-Targeted?Phase-Transition?Nanoparticles?for the?Detection?and?Treatment?of?AtheroscleroticVulnerable?Plaques. ACS Appl Mater Interfaces.?2019 Mar 13;11(10):9702-9715.  IHC ;  Mouse.  
[IF=7.666] Ryo Honma. et al. Immunomodulatory Macrophages Enable E-MNC Therapy for Radiation-Induced Salivary Gland Hypofunction. CELLS-BASEL. 2023 Jan;12(10):1417  ICC ;  Mouse.  
[IF=6.832] Yanhong Li. et al. Therapeutic potential of human umbilical cord mesenchymal stem cells on aortic atherosclerotic plaque in a high-fat diet rabbit model. Stem Cell Res Ther. 2021 Dec;12(1):1-14  IHC ;  Rabbit.  
[IF=5.442] Boxing Su. et al. Let-7d inhibits intratumoral macrophage M2 polarization and subsequent tumor angiogenesis by targeting IL-13 and IL-10. 2020 Nov 25  IHC ;  Human.  
[IF=4.784] Zhan Q et al. Structural Characterization and Immunomodulatory Activity of a Novel Acid Polysaccharide Isolated from the Pulp of Rosa laevigata Michx Fruit. Int J Biol Macromol. 2019 Nov 12. pii: S0141-8130(19)37108-9.  Other ;  Mouse.  
[IF=4.307] Mayuko Ichimura-Shimizu. et al. A novel mouse model of non-alcoholic steatohepatitis suggests that liver fibrosis initiates around lipid-laden macrophages. Am J Pathol. 2021 Oct;:  IF ;  Mouse.  
[IF=4.109] Yu Haiyi. et al. The Foam Cell Formation Associated With Imbalanced Cholesterol Homeostasis Due to Airborne Magnetite Nanoparticles Exposure. TOXICOL SCI. 2022 Aug;:  WB ;  Mouse, Human.  
[IF=1.632] Liu Y et al. Isolation and characterization of ovine monocyte-derived macrophages from peripheral blood.(2018)Vet Immunol Immunopathol. Nov;205:83-92.  IF ;  Sheep.  
[IF=0] Yamano et al. Role of deltaNp63(pos) CD44v(pos) cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas. (2016) Cancer.Sci. 107:123-32  IHC ;  Mouse.  
研究領(lǐng)域 心血管  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Mouse,Rat
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50 kDa
檢測分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MSR1/CD204: 211-320/451 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

Function:
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL.

Subunit:
Homotrimer.

Subcellular Location:
Membrane; Single-pass type II membrane protein.

Tissue Specificity:
Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.

DISEASE:
Defects in MSR1 may be a cause of prostate cancer (PC)[MIM:176807]. A malignancy originating in tissues of the prostate.Most prostate cancers are adenocarcinomas that develop in the aciniof the prostatic ducts. Other rare histopathologic types ofprostate cancer that occur in approximately 5% of patients includesmall cell carcinoma, mucinous carcinoma, prostatic ductalcarcinoma, transitional cell carcinoma, squamous cell carcinoma,basal cell carcinoma, adenoid cystic carcinoma (basaloid),signet-ring cell carcinoma and neuroendocrine carcinoma. Note=MSR1variants may play a role in susceptibility to prostate cancer. MSR1variants have been found in individuals with prostate cancer andco-segregate with the disease in some families.
Defects in MSR1 may be a cause of Barrett esophagus (BE)[MIM:614266]. A condition characterized by a metaplastic change inwhich normal esophageal squamous epithelium is replaced by acolumnar and intestinal-type epithelium. Patients with Barrettesophagus have an increased risk of esophageal adenocarcinoma. Themain cause of Barrett esophagus is gastroesophageal reflux. Theretrograde movement of acid and bile salts from the stomach intothe esophagus causes prolonged injury to the esophageal epitheliumand induces chronic esophagitis, which in turn is believed totrigger the pathologic changes. Note=Genetic variants in MSR1 havebeen found in individuals with Barrett esophagus and are thought tocontribute to disease susceptibility.

Similarity:
Contains 1 collagen-like domain.
Contains 1 SRCR domain.

SWISS:
P21757

Gene ID:
4481

Database links:

Entrez Gene: 281311 Cow

Entrez Gene: 4481 Human

Entrez Gene: 498638 Rat

Omim: 153622 Human

SwissProt: P21758 Cow

SwissProt: P21757 Human

Unigene: 147635 Human

Unigene: 231068 Rat



產(chǎn)品圖片
Sample: Lane 1: Spleen (Mouse) Lysate at 40 ug Lane 2: Lung (Mouse) Lysate at 40 ug Lane 3: Liver (Mouse) Lysate at 40 ug Lane 4: Placenta (Mouse) Lysate at 40 ug Lane 5: Cerebrum (Mouse) Lysate at 40 ug Lane 6: Raw264.7 (Mouse) Cell Lysate at 30 ug Lane 7: NIH/3T3 (Mouse) Cell Lysate at 30 ug Lane 8: Liver (Rat) Lysate at 40 ug Lane 9: Cerebrum (Rat) Lysate at 40 ug Primary: Anti-MSR1 (bs-6763R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50/39 kD Observed band size: 50 kD
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