亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
亚洲欧洲中文日韩AV无码,毛片视频在线免费观看,欧美激情综合色综合啪啪五月
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
GLE1 Rabbit pAb (bs-13371R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產(chǎn)品編號 bs-13371R
英文名稱 GLE1 Rabbit pAb
中文名稱 核孔蛋白GLE1抗體
別    名 GLE 1; GLE1; GLE1 like protein; GLE1 like RNA export mediator; GLE1 RNA export mediator homolog; GLE1 RNA export mediator like(yeast); GLE1-like protein; GLE1_HUMAN; GLE1L; hGLE1; LCCS 1; LCCS; LCCS1; Nucleoporin GLE1.  
研究領域 染色質(zhì)和核信號  信號轉(zhuǎn)導  轉(zhuǎn)運蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Rat (predicted: Human,Mouse,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 80 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GLE1: 611-698/698 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors that mediate protein passage through the nuclear pore complex (NPC). Gle1, also known as GLE1L, is a 698 amino acid protein that localizes to both the nucleus and the cytoplasm and belongs to the Gle1 family. Expressed as two alternatively spliced isoforms, Gle1 associates with the NPC and is required for the transport of poly(A)-containing mRNAs from the nucleus to the cytoplasm. Defects in the gene encoding Gle1 are the cause of lethal congenital contracture syndrome type 1 (LCCS1) and lethal arthrogryposis with anterior horn cell disease (LAAHD), the former of which is characterized by early fetal hydrops and akinesia, micrognatia, pulmonary hypoplasia, pterygia and prenatal death, while the latter is associated with respiratory failure.

Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).

Subunit:
Associated with the NPC, it however may not be a stable component of the NPC complex since it shuttles between the nucleus and the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and NUPL2. Isoform 2 does not interact with NUPL2. Able to form a heterotrimer with NUP155 and NUPL2 in vitro.

Subcellular Location:
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Shuttling is essential for its mRNA export function and Cytoplasm. Nucleus > nuclear pore complex. Shuttles between the nucleus and the cytoplasm. In the nucleus, isoform 1 localizes to the nuclear pore complex and nuclear envelope. Shuttling is essential for its mRNA export function.

DISEASE:
Defects in GLE1 are the cause of lethal congenital contracture syndrome type 1 (LCCS1) [MIM:253310]; also known as multiple contracture syndrome type Finnish. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, micrognatia, pulmonary hypoplasia, pterygia, multiple joint contractures, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS1 leads to prenatal death. Defects in GLE1 are the cause of lethal arthrogryposis with anterior horn cell disease (LAAHD) [MIM:611890]. LAAHD is characterized by fetal akinesia, arthrogryposis and motor neuron loss. LAADH fetus often survive delivery, but die early as a result of respiratory failure. Neuropathological findings resemble those of LCCS1, but are less severe.

Similarity:
Belongs to the GLE1 family.

SWISS:
Q53GS7

Gene ID:
2733

Database links:

Entrez Gene: 2733 Human

Entrez Gene: 74412 Mouse

Entrez Gene: 362098 Rat

GenBank: BC030012 Human

Omim: 603371 Human

SwissProt: Q53GS7 Human

SwissProt: Q8R322 Mouse

SwissProt: Q4KLN4 Rat

Unigene: 522418 Human

Unigene: 275121 Mouse

Unigene: 162648 Rat



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GLE1) Polyclonal Antibody, Unconjugated (bs-13371R) at 1:5000 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
亚洲欧洲另类春色校园小说 | 在线视频一区二区三区在线播放 | 欧美亚洲日本一区二区三区浪人 | 亚洲精品欧美精品日韩精品 | 污污内射久久一区二区 | 免费看的一级毛片 | 免费永久在线观看黄网站 | 性一交一无一伦一精一品的意思 | 免费国产动漫美女被靠的视频 | 色一情一乱一乱一区91Av | 日日噜噜夜夜狠狠久久丁香五月 | 久久久久久人妻精品三区 | 五月天综合网缴情五月中文 | 国产精品系列在线一区 | 国产欧美日韩网站 | 成年女人免费看一级人体片 | 国产精品第1页在线观看 | 日韩福利视频精品专区 | 国产成A人亚洲精V品无码樱花 | 性生交片免费无码看人 | 91精品国产无码高清 | 国产精品jizz在线观看老狼 | 国产精品 久久久精品软件下载 | 香港日本三级在线播放 | 少妇被躁爽到高潮无码麻豆AV | 免费无码又爽又黄又刺激网站 | 国产日韩精品一区二区在线观看 | 国产精品精品久久久久久 | 亚洲欧美日韩国产专区一区 | 亚洲国产成人久久综合一区77 | 日欧一片内射va在线影院 | 久久久精品国产亚洲AV无码 | 我和闺蜜在公车被cao污文 | 高h肉肉免费全部视频观看 bbbbbxxxxx精品人 | **女人一级毛片免费视频观看 | 亚洲另类小说交换 | 激情动图欧美一区二区 | 精品国产乱码久久久久久浪潮小说 | 午夜性色一区二区三区不卡视频 | 国产对白国语对白 | 精品21国产成人综合网在线 |