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SCP3 Rabbit pAb (bs-10660R)  
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產品編號 bs-10660R
英文名稱 SCP3 Rabbit pAb
中文名稱 膽堿磷酸轉移酶1抗體
別    名 SCP3; choline phosphotransferase 1; chpt1; COR 1; COR1; MGC71888; RNASCP3; SCP 3; SCP-3; SPGF4; Sycp 3; Sycp3; SYCP3_HUMAN; Synaptonemal complex protein 3.  
Specific References  (1)     |     bs-10660R has been referenced in 1 publications.
[IF=6.208] Baohui Yao. et al. Reproductive Suppression Caused by Spermatogenic Arrest: Transcriptomic Evidence from a Non-Social Animal. INT J MOL SCI. 2023 Jan;24(5):4611  IHC ;  Zokor.  
研究領域 細胞生物  染色質和核信號  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 27 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SYCP3: 151-236/236 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]

Function:
Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2.

Subunit:
Interacts with SYCP2.

Subcellular Location:
Nucleus. Chromosome. Note=In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed.

Tissue Specificity:
Testis-specific.

Post-translational modifications:
Phosphorylated.

DISEASE:
Spermatogenic failure 4 (SPGF4) [MIM:270960]: An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the XLR/SYCP3 family.

SWISS:
Q8IZU3

Gene ID:
50511

Database links:

Entrez Gene: 50511 Human

Entrez Gene: 20962 Mouse

Entrez Gene: 25561 Rat

Omim: 604759 Human

SwissProt: Q8IZU3 Human

SwissProt: P70281 Mouse

SwissProt: Q63520 Rat

Unigene: 506504 Human

Unigene: 297977 Mouse

Unigene: 34889 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SCP3) Polyclonal Antibody, Unconjugated (bs-10660R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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