| 產(chǎn)品編號(hào) | bs-17689R |
| 英文名稱 | MMS22L/C6orf167 Rabbit pAb |
| 中文名稱 | 6號(hào)染色體開放閱讀框抗體 |
| 別 名 | C6orf167; C6orf167 chromosome 6 open reading frame 167; chromosome 6 open reading frame 167; dJ39B17.2; DKFZp686C20164; DKFZp781C2113; FLJ46180; homologous to yeast Mms22; KIAA1900; Methyl methanesulfonate-sensitivity protein 22-like; MMS22 like, DNA repa |
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Specific References (1) | bs-17689R has been referenced in 1 publications.
[IF=6.244] Qiyu Luo. et al. MMS22L Expression as a Predictive Biomarker for the Efficacy of Neoadjuvant Chemoradiotherapy in Oesophageal Squamous Cell Carcinoma. Front Oncol. 2021; 11: 711642 IHC ; Human.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 糖尿病 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 142 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MMS22L/C6orf167: 451-550/1243 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf167 gene product has been provisionally designated C6orf167 pending further characterization. Function: Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Subcellular Location: Nucleus. Localizes to DNA damage sites, accumulates at stressed replication forks. Similarity: Belongs to the MMS22 family. MMS22L subfamily. SWISS: Q6ZRQ5 Gene ID: 253714 Database links: Entrez Gene: 253714 Human Entrez Gene: 212377 Mouse SwissProt: Q6ZRQ5 Human SwissProt: B1AUR6 Mouse Unigene: 444292 Human Unigene: 120919 Mouse |
