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mGluR6 Rabbit pAb (bs-18802R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-18802R
英文名稱 mGluR6 Rabbit pAb
中文名稱 促代謝型谷氨酸受體6抗體
別    名 Metabotropic Glutamate Receptor 6; CSNB1B; DKFZp686H1993; GluR6; Glutamate receptor metabotropic 6; GPRC1F; GRM6; GRM6_HUMAN; Metabotropic glutamate receptor 6; mGlu6; mGluR6.  
研究領域 細胞生物  神經(jīng)生物學  信號轉(zhuǎn)導  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 33, 95 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human mGluR6: 501-600/877 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]

Function:
Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.

Subunit:
Homodimer.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Detected in melanocytes.

DISEASE:
Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B) [MIM:257270]. This disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background.

Similarity:
Belongs to the G-protein coupled receptor 3 family.

SWISS:
O15303

Gene ID:
2916

Database links:

Entrez Gene: 2916 Human

Entrez Gene: 108072 Mouse

Entrez Gene: 100009501 Rabbit

Entrez Gene: 24419 Rat

Omim: 604096 Human

SwissProt: O15303 Human

SwissProt: Q5NCH9 Mouse

SwissProt: Q863I4 Rabbit

SwissProt: P35349 Rat

Unigene: 248131 Human

Unigene: 134265 Mouse

Unigene: 44615 Rat



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