亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
久久亚洲AⅤ精品网站,精人妻无码一区二区三区,欧美精品专区第1页
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
DCP1A Rabbit pAb (bs-10788R)  
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)

產(chǎn)品編號(hào) bs-10788R
英文名稱 DCP1A Rabbit pAb
中文名稱 脫帽酶1A抗體
別    名 DCP1 decapping enzyme homolog A; Dcp1a; DCP1A_HUMAN; mRNA decapping enzyme 1A; mRNA-decapping enzyme 1A; Smad4 interacting transcriptional co activator; Smad4-interacting transcriptional co-activator; Smad4-interacting transcriptional co-activator; SMAD4IP1; SMIF; Transcription factor SMIF.  
研究領(lǐng)域 染色質(zhì)和核信號(hào)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Rat (predicted: Human,Mouse,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 63 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DCP1A: 501-582/582 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Cleavage of the 5'-cap structure is involved in the major 5'-to-3' and nonsense-mediated mRNA decay pathways. The protein complex consisting of Dcp1 and Dcp2 has been identified as the species responsible for the decapping reaction in Saccharomyces cerevisiae. In nonsense-mediated decay, the human decapping complex, made up of S. cerevisiae homologs hDcp1a and hDcp2, may be recruited to mRNAs containing premature termination codons by nonsense-mediated decay factor (Upf) proteins. hDcp2 specifically hydrolyzes methylated capped RNA to release m(7)GDP, thereby aiding in mRNA degradation. Both hDcp1a and hDcp2 colocalize in the cytoplasm. In addition, hDcp1a interacts with Smad4 forming a complex with TGF Beta and BMP-4. hDcp1a and Smad4 interact directly through a EVH1/WH1 domain on hDcp1a and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of hDcp1a as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of hDcp1a eliminates TGF Beta-induced nuclear translocation of hDcp1a.

Function:
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.

Subunit:
Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Binds DCP1B, UPF1 and SMAD4. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with PNRC2. Interacts with DDX17 in an RNA-independent manner. Interacts with ZC3HAV1.

Subcellular Location:
Cytoplasm, P-body. Nucleus. Co-localizes with NANOS3 in the processing bodies. Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4.

Tissue Specificity:
Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.

Similarity:
Belongs to the DCP1 family.

SWISS:
Q9NPI6

Gene ID:
55802

Database links:

Entrez Gene: 55802 Human

Entrez Gene: 75901 Mouse

Entrez Gene: 361109 Rat

Omim: 607010 Human

SwissProt: Q9NPI6 Human

SwissProt: Q91YD3 Mouse

Unigene: 476353 Human

Unigene: 28733 Mouse

Unigene: 206852 Rat



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (DCP1A) Polyclonal Antibody, Unconjugated (bs-10788R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
www.一级毛片 | 免费在线观看疯狂做受XXXX | 欧美精品黄网站在线播放 | 欧美又大又硬又粗BBBBB | 小呦精品导航网站 | 18以下不能看的美女视频 | 亚洲AV无一区二区三区久久 | 亚洲国产女人aaa毛片在线 | 亚洲欧美日韩国产综合五月天 | 欧洲美女人**一级毛片 | 亚洲欧洲日产国码久在线 | 日韩AV在线高清免费毛片 | 人人妻人人添人人爽欧美一区91 | 熟妇高潮一区二区在线播放 | 国产V片在线播放免费观看大全 | 国产香蕉97碰碰久久人人蜜桃 | 一区二区三区日韩免费播放 | 国产乱熟肥女视频网站 | 欧美人成片免费看视频不卡 | 欧美人妻少妇精品视频专区 | 麻豆精品一区二正一三区 | 欧美日韩国产无线码一区 | 一级毛片正片免费视频手机看 | 色一情一乱一乱一区91Av | 国产99在线a视频 | 久久久精品日韩免费观看 | 91福利国产在线观看网站 | 婷婷国产精品久久久久精 | 熟女国产精品视频一区二区三区 | 色婷婷综合激情中文在线 | 毛片TV网站无套内射TV网站 | 好爽别插了无码视频 | 久久九九日本韩国精品 | hot亚洲欧美日韩精品久久视频在线播放 | 欧美高清免费精品国产自 | 亚洲成人电影在线观看精品国产 | 久久久国产精品免费看 | 国产精品一区二区三区四区五区 | 国产日产欧产精品精乱了派 | 成年轻人网站免费视频 | 国产又大又粗又长硬又紧又爽 |