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p66 beta/GATAD2B Rabbit pAb (bs-21073R)  
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產(chǎn)品編號(hào) bs-21073R
英文名稱(chēng) p66 beta/GATAD2B Rabbit pAb
中文名稱(chēng) p66β蛋白抗體
別    名 C430014D17Rik; FLJ37346; GATA zinc finger domain containing 2B; GATA zinc finger domain containing protein 2B; GATA zinc finger domain-containing protein 2B; GATAD2B; KIAA1150; MGC138257; MGC138285; mKIAA1150; p66/p68; P66B_HUMAN; P66beta; RGD1308533; RP1  
研究領(lǐng)域 細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀(guān)遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat,Rabbit,Pig,Sheep,Cow,Zebrafish,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 66 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human p66 beta: 381-480/593 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with mental retardation. [provided by RefSeq, Jun 2016]

Function:
Has transcriptional repressor activity. Targets MBD3 to discrete loci in the nucleus.

Subcellular Location:
Nucleus. Nuclear, in discrete foci.

Tissue Specificity:
Ubiquitous.

Similarity:
Contains 1 GATA-type zinc finger.

SWISS:
Q8WXI9

Gene ID:
57459

Database links:

Entrez Gene: 57459 Human

Entrez Gene: 229542 Mouse

Entrez Gene: 310614 Rat

SwissProt: Q8WXI9 Human

SwissProt: Q8VHR5 Mouse

Unigene: 4779 Human

Unigene: 596854 Human

Unigene: 270999 Mouse

Unigene: 133230 Rat



產(chǎn)品圖片
Sample: NIH/3T3(Mouse) Cell Lysate at 30 ug Hela(Human) Cell Lysate at 30 ug Primary: Anti-p66 beta (bs-21073R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 66 kD Observed band size: 66 kD
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (p66 beta/GATAD2B) Polyclonal Antibody, Unconjugated (bs-21073R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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