| 產(chǎn)品編號 | bs-20466R |
| 英文名稱 | CCL27 Rabbit pAb |
| 中文名稱 | 皮膚T細(xì)胞虜獲趨化因子抗體 |
| 別 名 | ALP; CTACK; C-C motif chemokine 27; CC chemokine ILC; Ccl27; CTAK; Cutaneous T cell attracting chemokine; Cutaneous T-cell-attracting chemokine; ESkine; IL 11 R alpha locus chemokine; IL-11 R-alpha-locus chemokine; PESKY; SCYA27; Skinkine; Small inducible |
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Specific References (1) | bs-20466R has been referenced in 1 publications.
[IF=3.269] Mengxue Zhang. et al. Identification and validation of potential novel biomarkers for oral squamous cell carcinoma. Bioengineered. 2021;12(1):8845-8862 IF,IHC ; Human,Mouse.
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| 研究領(lǐng)域 | 免疫學(xué) 趨化因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 19 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CCL27: 26-100/112 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq]. Function: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10. Subunit: Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization. Subcellular Location: Secreted. Tissue Specificity: Testis, thymus, placenta, ovary and skin. Similarity: Belongs to the intercrine beta (chemokine CC) family. SWISS: Q9Y4X3 Gene ID: 10850 Database links: Entrez Gene: 10850 Human Omim: 604833 Human SwissProt: Q9Y4X3 Human CCL27是一種CC型趨化因子，又被稱為Skinkine，ESkine和CTACK。CCL27基因位于人類染色體9，它與皮膚上歸巢的記憶T淋巴細(xì)胞有關(guān)，并在T細(xì)胞介導(dǎo)的皮膚炎癥中起著重要的作用。CCL27表達(dá)在許多組織，包括性腺，胸腺，胎盤和皮膚。其配體為CCR10,CCL27與接觸性軟疣病毒編碼產(chǎn)生的蛋白質(zhì)MC148有較高的同源性，但卻與人皰疹病毒8型編碼產(chǎn)生病毒巨噬細(xì)胞炎癥蛋白-Ⅱ競爭結(jié)合受體CCR10。 |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (Human prostate); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCL27) Polyclonal Antibody, Unconjugated (bs-20466R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Human stomach carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCL27) Polyclonal Antibody, Unconjugated (bs-20466R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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