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FPRL1 Rabbit pAb (bs-23765R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產(chǎn)品編號 bs-23765R
英文名稱 FPRL1 Rabbit pAb
中文名稱 脂氧素受體1抗體
別    名 ALXR; FMLP R I; FMLP R II; FMLP related receptor I; FMLP-R-I; FMLP-R-II; FMLP-related receptor I; FMLPX; Formyl peptide receptor 2; Formyl peptide receptor like 1; Formyl peptide receptor related; Formyl peptide receptor-like 1; FPR 2; FPR2; FPR2_HUMAN; F  
Specific References  (2)     |     bs-23765R has been referenced in 2 publications.
[IF=6.6] Ana Paula Girol. et al. Annexin A1 Mimetic Peptide and Piperlongumine: Anti-Inflammatory Profiles in Endotoxin-Induced Uveitis. Cells-Basel. 2021 Nov;10(11):3170  IHC ;  Rat.  
[IF=5.895] Hui Wang. et al. Effect of Chlorogenic Acid via Upregulating Resolvin D1 Inhibiting the NF-κB Pathway on Chronic Restraint Stress-Induced Liver Inflammation. J AGR FOOD CHEM. 2022;70(34):10532–10542  WB ;  Rat.  
研究領(lǐng)域 心血管  細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞粘附分子  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39 kDa
檢測分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human FPRL1: 1-100/350 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 FPRL1 is a low affinity receptor to N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). FPRL1 has been reported in phagocytes, monocytes, neutrophils, differentiated myeloid cells from bone marrow, granulocyte HL-60 cells, and synovial fibroblasts. ESTs have been isolated from blood, leukocyte, lung, and placenta libraries.

Function:
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P25090

Gene ID:
2358

Database links:
Entrez Gene: 2358 Human

Omim: 136538 Human

SwissProt: P25090 Human

Unigene: 99855 Human



脂氧素受體廣泛表達(dá)于各類炎癥相關(guān)細(xì)胞并受多種炎癥刺激的調(diào)節(jié),通過PKA、PKC、MAPK等一系列信號途徑參與控制炎癥的發(fā)生發(fā)展。
產(chǎn)品圖片
Sample: SW480(Human) Cell Lysate at 30 ug LOVO(Human) Cell Lysate at 30 ug Primary: Anti-FPRL1 (bs-23765R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 39 kD
Sample: Bone (Mouse) Lysate at 40 ug Primary: Anti- FPRL1 (bs-23765R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 39 kD
Sample: Lane 1: U937 (Human) Cell Lysate at 30 ug Lane 2: HL60 (Human) Cell Lysate at 30 ug Lane 3: Hela (Human) Cell Lysate at 30 ug Lane 4: HepG2 (Human) Cell Lysate at 30 ug Lane 5: SW480 (Human) Cell Lysate at 30 ug Lane 6: Lovo (Human) Cell Lysate at 30 ug Primary: Anti-FPRL1 (bs-23765R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 35 kD
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