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CRIM-1 Rabbit pAb (bs-21654R)  
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產(chǎn)品編號 bs-21654R
英文名稱 CRIM-1 Rabbit pAb
中文名稱 富含半胱氨酸運動神經(jīng)元蛋白1抗體
別    名 Cysteine-rich motor neuron 1 protein; CRIM-1; Cysteine-rich repeat-containing protein S52; Processed cysteine-rich motor neuron 1protein; CRIM 1; CRIM1; Cysteine rich motor neuron 1 protein; Cysteine rich repeat containing protein S52; Cysteine rich transmembrane BMP regulator 1(chordin like); Cysteine rich transmembrane BMP regulator 1; MGC138194; Processed cysteine rich motor neuron 1 protein; S52; CRIM1_HUMAN.  
研究領(lǐng)域 心血管  細(xì)胞生物  染色質(zhì)和核信號  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  血管內(nèi)皮細(xì)胞  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Mouse (predicted: Human,Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 110 kDa
檢測分子量
細(xì)胞定位 細(xì)胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRIM-1: 641-740/1036 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 CRIM1 interacts with BMP4 (bone morphogenic protein 4) and BMP7 and modulates BMP activity by affecting their processing and delivery to the cell surface. By interacting with growth factors implicated in motor neuron differentiation and survival, it may play a role in CNS development. It may also play a role in capillary formation and maintenance during angiogenesis.

Function:
May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival.
May play a role in capillary formation and maintenance during angiogenesis.
Modulates BMP activity by affecting its processing and delivery to the cell surface.

Subcellular Location:
Secreted and Cell membrane.

Tissue Specificity:
Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).

Post-translational modifications:
N-glycosylated.

Similarity:
Contains 4 antistasin-like domains.
Contains 1 IGFBP N-terminal domain.
Contains 6 VWFC domains.

SWISS:
Q9NZV1

Gene ID:
51232

Database links:

Entrez Gene: 51232 Human

Entrez Gene: 50766 Mouse

Omim: 606189 Human

SwissProt: Q9NZV1 Human

SwissProt: Q9JLL0 Mouse

Unigene: 699247 Human



產(chǎn)品圖片
Sample: Uterus (Mouse) Lysate at 40 ug Primary: Anti- CRIM-1 (bs-21654R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 110 kD Observed band size: 110 kD
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