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PTN Rabbit pAb (bs-21928R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價(jià)

產(chǎn)品編號 bs-21928R
英文名稱 PTN Rabbit pAb
中文名稱 多效生長因子抗體
別    名 pleiotrophin; HARP; HBBM; HBGAM; HBGF8; HBNF; HBNF1; Heparin Binding Growth Factor 8; Heparin binding neurite outgrowth promoting factor 1; heparin-binding growth associated molecule; NEGF1; Neurite Growth Promoting Factor 1; OSF-1; osteoblast-specific fa  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  生長因子和激素  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat (predicted: Human,Rabbit,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 15 kDa
檢測分子量
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTN: 101-168/168  
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Pleiotrophin is a heparin-binding growth factor involved in the differentiation and proliferation of neuronal tissue during embryogenesis, and also secreted by melanoma and breast carcinoma cells. Pleiotrophin exhibits mitogenic and angiogenic properties and has been shown to influence the vascular supply, expansion and metastasis of tumour cells.

Function:
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.

Subunit:
Interacts with ALK and NEK6.

Subcellular Location:
Secreted.

Tissue Specificity:
Osteoblast and brain.

Post-translational modifications:
Phosphorylated by NEK6.

Similarity:
Belongs to the pleiotrophin family.

SWISS:
P21246

Gene ID:
5764

Database links:
Entrez Gene: 5764 Human

Entrez Gene: 19242 Mouse

Entrez Gene: 24924 Rat

Omim: 162095 Human

SwissProt: P21246 Human

SwissProt: P63089 Mouse

SwissProt: P63090 Rat

Unigene: 371249 Human

Unigene: 279690 Mouse

Unigene: 1653 Rat



多效生長因子(pleiotrophin)是一種分泌性的生長因子,具有促進(jìn)腫瘤細(xì)胞的增殖與遷移,對腫瘤血管的生成有促進(jìn)作用。
產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PTN) Polyclonal Antibody, Unconjugated (bs-21928R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PTN) Polyclonal Antibody, Unconjugated (bs-21928R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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