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EP4 Rabbit pAb (bs-24918R)  
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50ul/1180.00元
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產(chǎn)品編號(hào) bs-24918R
英文名稱(chēng) EP4 Rabbit pAb
中文名稱(chēng) 前列腺素E受體蛋白4抗體
別    名 Prostaglandin E Receptor EP4; EP 4; EP4; EP-4; EP4R; MGC126583; PE2R4_HUMAN; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostaglandin E receptor 4; Prostaglandin E receptor 4 subtype EP4; Prostaglandin E2 receptor; Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor; PTGER 2; PTGER 4; PTGER2; PTGER4.  
研究領(lǐng)域 信號(hào)轉(zhuǎn)導(dǎo)  G蛋白偶聯(lián)受體  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Mouse
產(chǎn)品應(yīng)用 WB=1:500-2000,Flow-Cyt=2ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 53 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse EP4 : 1-100/513 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

Function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

Subunit:
Interacts with FEM1A.

Subcellular Location:
Cell membrane.

Tissue Specificity:
High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.

Post-translational modifications:
Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P32240

Gene ID:
19219

Database links:

Entrez Gene: 5734 Human

Entrez Gene: 19219 Mouse

Entrez Gene: 84023 Rat

Entrez Gene: 443222 Sheep

Omim: 601586 Human

SwissProt: P35408 Human

SwissProt: P32240 Mouse

SwissProt: P43114 Rat

Unigene: 199248 Human

Unigene: 18509 Mouse

Unigene: 16062 Rat



產(chǎn)品圖片
Sample: Lane 1: Mouse Uterus tissue lysates Lane 2: Mouse Small intestine tissue lysates Lane 3: Mouse Kidney tissue lysates Lane 4: Mouse Prostate tissue lysates Primary: Anti-EP4 (bs-24918R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 55 kD
Blank control:Ctll-2. Primary Antibody (green line): Rabbit Anti-EP4 antibody (bs-24918R) Dilution: 2ug/Test; Secondary Antibody : Goat anti-rabbit IgG-FITC Dilution: 0.5ug/Test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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