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CEBP Beta Rabbit pAb (bs-25032R)  
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產品編號 bs-25032R
英文名稱 CEBP Beta Rabbit pAb
中文名稱 轉錄調節(jié)因子C/EBP β抗體
別    名 CEBP-beta; CLEBP beta; CCAAT Enhancer Binding Protein beta; AGP/EBP; C EBP beta; C/EBP related protein 2; CEBPB; CRP2; IL 6DBP; IL6DBP; Interleukin 6 dependent binding protein; LAP; Liver enriched transcriptional activator; NF IL6; NFIL6; Nuclear factor NF IL6; SF B; SFB; Silencer factor B; TCF5; Transcription factor 5; C/EBP beta; CCAAT/enhancer-binding protein beta; CEBPB_HUMAN; Liver activator protein; Liver enriched transcriptional activator; Nuclear factor NF IL6; Nuclear factor NF-IL6; TCF-5.  
研究領域 腫瘤  染色質和核信號  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse,Rat (predicted: Human,Rabbit,Pig,Dog)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 36 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CEBP Beta: 21-120/345 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq].

Function:
Involved in interleukin-6 signal transduction, including the transcriptional activation of acute-phase genes. Functions in brown adipose tissue (BAT) differentiation.

Subunit:
Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and gamma. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B.

Subcellular Location:
Nucleus.

Post-translational modifications:
Sumoylated by polymeric chains of SUMO2 or SUMO3.

Similarity:
Belongs to the bZIP family. C/EBP subfamily.
Contains 1 bZIP domain.

SWISS:
P17676

Gene ID:
1051

Database links:

Entrez Gene: 1051 Human

Entrez Gene: 12608 Mouse

Entrez Gene: 24253 Rat

Omim: 189965 Human

SwissProt: P17676 Human

SwissProt: P28033 Mouse

SwissProt: P21272 Rat

Unigene: 517106 Human

Unigene: 719041 Human

Unigene: 720603 Human

Unigene: 439656 Mouse

Unigene: 6479 Rat




轉錄調節(jié)因子(Transcriptin Regulators)
產品圖片
Sample: Lane 1: Mouse Liver tissue lysates Lane 2: Rat Liver tissue lysates Primary: Anti-CEBP Beta (bs-25032R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kDa Observed band size: 35 kDa
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