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PTPN12 Recombinant Rabbit mAb (bsm-60705R)  
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25ul/800.00元
50ul/1400.00元
100ul/2500.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bsm-60705R
英文名稱 PTPN12 Recombinant Rabbit mAb
中文名稱 酪氨酸蛋白磷酸酶非受體型12重組兔單抗
別    名 PTN12_HUMAN; Tyrosine-protein phosphatase non-receptor type 12; EC:3.1.3.48; PTP-PEST; Protein-tyrosine phosphatase G1(PTPG1); protein tyrosine phosphatase non-receptor type 12; PTPG1; PTP-PEST;  
研究領(lǐng)域 細(xì)胞生物  染色質(zhì)和核信號(hào)  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Recombinant
克 隆 號(hào) R2C6
交叉反應(yīng) (predicted: Human,Mouse,Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 88 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTPN12 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]


Subcellular Location:
Cytoplasm.

SWISS:
Q05209

Gene ID:
5782

Database links:


Entrez Gene: 5782 Human

Entrez Gene: 19248 Mouse

Entrez Gene: 117255 Rat

SwissProt: Q05209 Human

SwissProt: P35831 Mouse

SwissProt: Q63745 Rat




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