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human CD3 (bsm-30092M-PerCP-Cy5.5)  
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產(chǎn)品編號(hào) bsm-30092M-PerCP-Cy5.5
英文名稱 human CD3
中文名稱 PerCP-Cy5.5標(biāo)記的小鼠抗人CD3單克隆抗體
別    名 CD3 epsilon; CD3e; CD3e antigen epsilon polypeptide (TiT3 complex); CD3E antigen epsilon polypeptide; CD3E antigen, epsilon subunit; CD3e molecule epsilon; CD3e molecule, epsilon (CD3 TCR complex); CD3e molecule, epsilon (CD3-TCR complex); CD3E_HUMAN; IMD18; T cell antigen receptor complex epsilon subunit of T3; T cell surface antigen T3/Leu 4 epsilon chain; T cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3E; TCRE.  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號(hào) HIT3b
交叉反應(yīng) (predicted: Human)
產(chǎn)品應(yīng)用 Flow-Cyt=10ul/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細(xì)胞定位 細(xì)胞膜 
免 疫 原 KLH conjugated synthetic peptide derived from human CD3 
亞    型 Mouse IgG2a, k
純化方法 affinity purified by Protein G
緩 沖 液 0.01M PBS (pH7.4), 0.5% BSA, 0.02% Proclin300.
保存條件 Store at 2-8℃. Protect from light. Avoid freezing.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

Function:
The CD3 complex mediates signal transduction.

Subunit:
he TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Contains 1 Ig-like (immunoglobulin-like) domain. Contains 1 ITAM domain.

Database links:

Entrez Gene : 916 Human

Entrez Gene : 12501 Mouse

Omim : 186830 Human

SwissProt : P07766 Human

SwissProt : P22646 Mouse

Unigene : 3003 Human

Unigene : 210361 Mouse



CD3 epsilon 參與T淋巴細(xì)胞介導(dǎo),主要用于免疫排斥方面的研究.
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