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Thyroid peroxidase Mouse mAb (bsm-34081M)  
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50ul/1180.00元
100ul/1980.00元
大包裝/詢價

產品編號 bsm-34081M
英文名稱 Thyroid peroxidase Mouse mAb
中文名稱 甲狀腺過氧化物酶抗體
別    名 MSA; PERT_HUMAN; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX.  
研究領域 腫瘤  細胞生物  免疫學  神經生物學  信號轉導  生長因子和激素  激酶和磷酸酶  內分泌病  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 6C3
交叉反應 Human
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 101 kDa
檢測分子量
細胞定位 細胞膜 細胞外基質 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Thyroid peroxidase 
亞    型 IgG2b,k
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011].

Function:
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

Subunit:
Interacts with DUOX1, DUOX2 and CYBA.

Subcellular Location:
Membrane; Single-pass type I membrane protein.
Isoform 3: Cell surface.

Post-translational modifications:
Glycosylated.
Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.

DISEASE:
Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
Defects in TPO are the cause of thyroid dyshormonogenesis 2A (TDH2A) [MIM:274500]. A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.

Similarity:
Belongs to the peroxidase family. XPO subfamily.
Contains 1 EGF-like domain.
Contains 1 Sushi (CCP/SCR) domain.

SWISS:
P07202

Gene ID:
7173

Database links:

Entrez Gene: 7173 Human

Omim: 606765 Human

SwissProt: P07202 Human

Unigene: 467554 Human



甲狀腺過氧化物酶TPO是一種含鐵卟啉的血紅蛋白類物質,位于甲狀腺上皮細胞的頂端細胞膜上。
TPO主要的生物學作用是使碘活化,酪氨酸碘化和促進碘化酪氨酸的耦聯(lián),在甲狀腺激素合成過程中起著關鍵作用-是甲狀腺激素合成過程中的關鍵酶.
產品圖片
Paraformaldehyde-fixed, paraffin embedded (human thyroid gland); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (hyroid peroxidase) Monoclonal Antibody, Unconjugated (bsm-34081M ) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
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