亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产午夜福利100集发布,欧美人成国产91视频
Rabbit Anti-RIN1/FITC Conjugated antibody (bs-6094R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-6094R-FITC
英文名稱 Rabbit Anti-RIN1/FITC Conjugated antibody
中文名稱 FITC標(biāo)記的RAS互動/干擾蛋白1抗體
別    名 Ras and Rab interactor 1; ras inhibitor 1; ras inhibitor; RIN1_HUMAN; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIN 1.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  染色質(zhì)和核信號  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  G蛋白偶聯(lián)受體  表觀遺傳學(xué)  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RIN1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
RIN1 is a Ras effector protein which can affect Ras signaling in a variety of ways. It enhances signaling from ABL1 and ABL2 whcih are involved in regulation of cytoskeletal remodeling. It may function as a guanine nucleotide exchange factor in activation of Rab5a. Rin1 also competes with RAF1 for binding of the activated form of Ras. It may play a role inhibiting the modulation of neuronal plasticity in formation of aversive memory, and has been implicated as a tumor supressor gene in breast cancer.

Function:
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Subunit:
Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.

Subcellular Location:
Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.

Tissue Specificity:
Expressed in all tissues examined with high levels in brain, placenta and pancreas.

Post-translational modifications:
Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins.

Similarity:
Belongs to the RIN (Ras interaction/interference) family.
Contains 1 Ras-associating domain.
Contains 1 SH2 domain.
Contains 1 VPS9 domain.

Database links:

Entrez Gene: 9610 Human

Entrez Gene: 225870 Mouse

Entrez Gene: 207119 Rat

Omim: 605965 Human

SwissProt: Q13671 Human

SwissProt: Q921Q7 Mouse

SwissProt: P97680 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产福利影院在线观看 | 亚洲日韩久久精品无码AV | 欧美日韩一区二区三区人妻 | 精品日产卡一卡二卡麻豆 | 国产一区二区三区AV天堂 | 亚洲伊人久久综合影院2021 | 亚洲日韩在线中文字幕一区 | 国产精品亚欧美一区二区 | 免费一级A片毛毛片在线播放99 | 中文字幕亚洲精品乱码APP | 天天躁日日躁狠狠躁日日躁黑人 | 免费看成人AA片无码视频吃奶 | 久久精品一区二区国产 | 国产精品色拉拉免费看 | 好大好深别停视频视频 | aaaaa级毛片 毛片线看免费观看 | 国产伦精品一区二区三区免费 | 日本又黄又裸一级大黄裸片 | 国产不卡视频在线观看 | 欧美日本高清动作片www网站 | 亚洲一区二区三区首页欧美 | 放荡的小峓子2中文字幕 | 亚洲AV中文无码字幕色三 | 国产在线高清视频 | 精品性影院一区二区三区内射 | 久99re视频9在线观看 | 嫩草在线视频WWW免费看 | 国产精品自产拍在线观看中文 | 亚洲天天在线日亚洲洲精 | 国产精品高清视亚洲一区二区 | 日产亚洲一卡2卡3卡4卡网站 | 亚洲精品ty久久久久久久久久 | 欧美成人精品视频在线播放 | 国产三级视频在线播放线观看 | 美女狂揉尿口揉到失禁 | 97在线精品视频免费 | 国产精品免费看久久久8 | 日韩AV片无码一区二区三区不卡 | 久久夜色撩人精品国产小说 | 一本视频精品中文字幕 | 日韩经典午夜福利发布 |