亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
男女无遮挡XX00动态图120秒,蹂躏清冷仙子翘臀雪乳
Rabbit Anti-RIN1/PE-Cy5 Conjugated antibody (bs-6094R-PE-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6094R-PE-Cy5
英文名稱 Rabbit Anti-RIN1/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的RAS互動(dòng)/干擾蛋白1抗體
別    名 Ras and Rab interactor 1; ras inhibitor 1; ras inhibitor; RIN1_HUMAN; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIN 1.   
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  G蛋白偶聯(lián)受體  表觀遺傳學(xué)  G蛋白信號(hào)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RIN1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
RIN1 is a Ras effector protein which can affect Ras signaling in a variety of ways. It enhances signaling from ABL1 and ABL2 whcih are involved in regulation of cytoskeletal remodeling. It may function as a guanine nucleotide exchange factor in activation of Rab5a. Rin1 also competes with RAF1 for binding of the activated form of Ras. It may play a role inhibiting the modulation of neuronal plasticity in formation of aversive memory, and has been implicated as a tumor supressor gene in breast cancer.

Function:
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Subunit:
Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.

Subcellular Location:
Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.

Tissue Specificity:
Expressed in all tissues examined with high levels in brain, placenta and pancreas.

Post-translational modifications:
Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins.

Similarity:
Belongs to the RIN (Ras interaction/interference) family.
Contains 1 Ras-associating domain.
Contains 1 SH2 domain.
Contains 1 VPS9 domain.

Database links:

Entrez Gene: 9610 Human

Entrez Gene: 225870 Mouse

Entrez Gene: 207119 Rat

Omim: 605965 Human

SwissProt: Q13671 Human

SwissProt: Q921Q7 Mouse

SwissProt: P97680 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
欧美性受XXXX黑人XYX性爽 | 国产欧美一区二区精品仙草咪 | 综合久久国产九一剧情麻豆 | 国产一区二区女内射 | 亚洲精品免费视频观看视频 | 亚洲欧美日韩综合在线观看 | 豪妇荡乳1一5潘金莲2 | 亚洲欧美日韩在线视频 | 日韩精品一区二区三区中文不卡 | 在线成人免费观看国产精品 | 国产成人Av大片在线观看 | 亚洲高清成人AV电影网站 | 中文字幕在线成人免费看 | 国产精品久久久久久亚洲小说 | 午夜女生自慰喷水在线 | 日韩欧美亚洲每日更新在线 | 免费精品国产自产拍在线观看图片 | 黄网站动漫免费永久在线观看网站入口 | 国产主播福利一区二区 | 国产毛片久久久久久国产毛片 | 亚洲国产精品日韩专区AV | 欧美性猛交XXXX乱大交极品 | 91免费精品国自产拍在线不卡 | 久爱成欢视频在线观看 | A级黄韩国在线观看免费 | 60老熟女多次高潮露脸视频 | 四川小少妇BBAABBAA | 无码精品人妻一区二美国区三区 | 婷婷伊人久久大香线蕉AV | a级毛片在线免费 | 巜豪妇荡乳2在线观看 | 久久婷婷五月综合色精品首页 | 0国产一级广片内射视频播放麻豆 | 日日躁夜夜躁狠狠久久AV | 国产AV一区二区三区天堂综合网 | 狠狠色噜噜狠狠狠777 | 大尺度很黄很肉的小说 | 久久精品WWW人人爽人人 | 久久久亚洲欧洲日产国码二区 | 年轻的护士3韩国三级 | 欧美一级又粗又大又黑 |