亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产精品户露AV在线户外直播,国产精品系列在线观看,开心婷婷五月综合基地
Rabbit Anti-Pokemon/ZBTB7A/PE-Cy5 Conjugated antibody (bs-0891R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0891R-PE-Cy5
英文名稱 Rabbit Anti-Pokemon/ZBTB7A/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的撲克蒙蛋白抗體
別    名 Factor binding IST protein 1; Factor that binds to inducer of short transcripts protein 1; FBI-1; FBI1; HIV-1 1st-binding protein 1; Leukemia/lymphoma related factor; LRF; Pokemon; TIP21; TTF-I interacting peptide 21; ZBTB7; ZBTB7A; Zinc finger and BTB domain-containing protein 7A; ZBT7A_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  微生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Pokemon
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Pokemon, the POK erythroid myeloid ontogenic factor, not only regulates the expression of many genes, but also plays an important role in cell tumorigenesis. To investigate the molecular mechanism regulating expression of the Pokemon gene in humans, its 5'-upstream region was cloned and analyzed. Transient analysis revealed that the Pokemon promoter is constitutive. Deletion analysis and a DNA decoy assay indicated that the NEG-U and NEG-D elements were involved in negative regulation of the Pokemon promoter, whereas the POS-D element was mainly responsible for its strong activity. Electrophoretic mobility shift assays suggested that the NEG-U, NEG-D and POS-D elements were specifically bound by the nuclear extract from A549 cells in vitro. Mutation analysis demonstrated that cooperation of the NEG-U and NEG-D elements led to negative regulation of the Pokemon promoter. Moreover, the NEG-U and NEG-D elements needed to be an appropriate distance apart in the Pokemon promoter in order to cooperate. Taken together, our results elucidate the mechanism underlying the regulation of Pokemon gene transcription, and also define a novel regulatory sequence that may be used to decrease expression of the Pokemon gene in cancer gene therapy.

Function:
Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'.

Subunit:
Interacts with BCL6.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level).

Similarity:
Contains 1 BTB (POZ) domain.
Contains 4 C2H2-type zinc fingers.

Database links:

Entrez Gene: 51341 Human

Entrez Gene: 16969 Mouse

Omim: 605878 Human

SwissProt: O95365 Human

SwissProt: O88939 Mouse

Unigene: 591384 Human

Unigene: 20920 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Pokemon(7APOK Erythroid Myeloid Ontogenic factor)能夠控制將正常細(xì)胞變成癌細(xì)胞所需的途徑,Pokemon蛋白是轉(zhuǎn)錄因子蛋白家族的一員,并且在人類癌癥中發(fā)生了突變。另外Pokemon蛋白作為轉(zhuǎn)錄因子參與一些細(xì)胞基因轉(zhuǎn)錄的調(diào)節(jié),并在細(xì)胞分化過程中發(fā)揮著關(guān)鍵、多效性的功能。近來發(fā)現(xiàn),Poke-mon在致癌轉(zhuǎn)化過程中發(fā)揮著至關(guān)重要的功能,并與腫瘤的發(fā)生密切相關(guān)。
這種蛋白很可能在實(shí)質(zhì)腫瘤中處于重要地位,還有學(xué)者認(rèn)為:Pokemon在一定類型的B細(xì)胞和T細(xì)胞淋巴瘤中水平非常高,并發(fā)現(xiàn)具有高水平Pokemon蛋白表達(dá)對腫瘤惡性程度改變更大。
主要定位于細(xì)胞核。
撲克蒙”蛋白又稱“波克曼”蛋白。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
91精品久久久久久久久久小网站 | 一女侍七夫巨H双修 | 一级毛片女人喷潮 | 欧美国产综合日韩一区二区 | 国产又爽又黄无码无遮挡在线观看 | 色婷婷国产精品无码视频 | 五月天婷五月天综合网 | 四虎影视一区二区精品 | 欧美激情性A片视频播放 | 国产又黄又爽胸又大免费视频 | 亚洲一区二区三区高清AV | 青青草原综合久久大伊人精品 | 看亚洲A级一级毛片,亚洲AV片 | 日韩一级视频在线观看播放 | www.色播.com| 教室啪啪高挑长腿正在播放 | 欧美一级视频精品观看 | 国产日韩精品中文字无码国产精品 | 国产激情久久久久99蜜桃小说 | 偷拍激情视频一区二区三区 | 久久久av久av久片一区二区 | AV午夜午夜快憣免费观看 | 粉嫩小泬流出白浆 | 内射干少妇亚洲69XXX | XX性欧美肥妇精品久久久久久 | 丰满少妇高潮惨叫久久久久 | 亚洲欧洲校园自拍都市 | 国产精品成人99久久久久 | 国产毛多水多高潮高清 | 日本免费一级婬片A级中文字幕 | 嫩B人妻精品一区二区三区 女人和拘做受全过程免费 日本亚洲一区二区三区 | 精品国产午夜福利精品推荐 | 全免费A级毛片免费看无码播放 | 精品黄毛片久久99国产 | 免费无码又爽又刺激网站直播 | 亚洲高清在线精品一区 | 伊人激情AV一区二区三区 | 狼人香蕉香蕉在线28 - 百度 | 中文韩国日本免费不卡五月天成人 | 国产AV一区二区三区传媒 | 激情综合激情五月俺也去 |