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Rabbit Anti-Rab3A+Rab3B+Rab3C+Rab3D/BF488 Conjugated antibody (bs-6180R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-6180R-BF488
英文名稱 Rabbit Anti-Rab3A+Rab3B+Rab3C+Rab3D/BF488 Conjugated antibody
中文名稱 BF488標記的ras癌基因家族Rab3A--Rab3D抗體
別    名 RAB3A; RAB3A member RAS oncogene family; RAB3B; RAB3B member RAS oncogene family; RAB3C; RAB3C member RAS oncogene family; RAB3D member RAS oncogene family; RAD3D; Ras related protein Rab 3A; Ras related protein Rab 3B; Ras related protein Rab 3C; Ras related protein Rab 3D; D2 2; Glioblastoma overexpressed; GOV; RAB16.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 神經(jīng)生物學  信號轉(zhuǎn)導  轉(zhuǎn)錄調(diào)節(jié)因子  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 24-27kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Rab3A+Rab3B+Rab3C+Rab3D
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Rab proteins belong to the Ras small GTPase superfamily. The GTP-binding Rab3 subfamily has four known isoforms: 3A, 3B, 3C and 3D. These proteins are expressed in the highest concentration in the brain and endocrine tissues and are involved in regulated exocytosis of hormones and neurotransmitters. Specifically Rab3's are thought to play a role in presynaptic vesicle trafficking and priming.

Function:
Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

Subunit:
Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A and RPH3AL. Interacts with the exocyst complex through SEC15. Binds SYTL4 and RIMS1. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3.

Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side.

Tissue Specificity:
Specifically expressed in brain.

Similarity:
Belongs to the small GTPase superfamily. Rab family.

Database links:

Entrez Gene: 115827 Human

Entrez Gene: 5864 Human

Entrez Gene: 5865 Human

Entrez Gene: 9545 Human

Entrez Gene: 19339 Mouse

Entrez Gene: 19340 Mouse

Entrez Gene: 67295 Mouse

Entrez Gene: 69908 Mouse

Entrez Gene: 140665 Rat

Entrez Gene: 171058 Rat

Entrez Gene: 25531 Rat

Entrez Gene: 81755 Rat

Entrez Gene: 399230 Xenopus laevis

Entrez Gene: 495404 Xenopus laevis

Omim: 179490 Human

Omim: 179510 Human

Omim: 604350 Human

SwissProt: O95716 Human

SwissProt: P20336 Human

SwissProt: P20337 Human

SwissProt: Q5VUL2 Human

SwissProt: Q96E17 Human

SwissProt: P35276 Mouse

SwissProt: P62823 Mouse

SwissProt: P63011 Mouse

SwissProt: Q0PD62 Mouse

SwissProt: Q0PD63 Mouse

SwissProt: Q9CZT8 Mouse

SwissProt: Q9JME6 Mouse

SwissProt: P62824 Rat

SwissProt: P63012 Rat

SwissProt: Q63941 Rat

SwissProt: Q63942 Rat

SwissProt: Q6P9W6 Rat

SwissProt: Q3KQA5 Xenopus laevis

Unigene: 123072 Human

Unigene: 27744 Human

Unigene: 482173 Human

Unigene: 8036 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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