亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲精品综合在线发布,亚洲999精品视频免费观看
Rabbit Anti-HEF1/Cy3 Conjugated antibody (bs-6265R-Cy3)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6265R-Cy3
英文名稱 Rabbit Anti-HEF1/Cy3 Conjugated antibody
中文名稱 Cy3標(biāo)記的蛋白激酶底物相關(guān)蛋白抗體
別    名 CAS L; Cas like docking; Cas scaffolding protein family member 2; CAS-L; CAS2; CASL; CASL_HUMAN; CASS2; Crk associated substrate related protein; CRK-associated substrate-related protein; dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)); Enhancer of filamentation 1; Enhancer of filamentation 1 p55; HEF 1; HEF1; NEDD 9; NEDD-9; NEDD9; NEDD9 protein; Neural cell expressed developmentally down regulated 9; Neural precursor cell expressed developmentally down regulated 9; Neural precursor cell expressed developmentally down-regulated protein 9; NY REN 12 antigen antibody p105; Protein NEDD9; Renal carcinoma antigen NY-REN-12.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  激酶和磷酸酶  t-淋巴細(xì)胞  b-淋巴細(xì)胞  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 92kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HEF1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.

Function:
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.

Subunit:
Interacts with BCAR3 and SH2D3C. Homodimer. Can heterodimerize with HLH proteins ID2, E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK), adapter protein CRKL and LYN kinase. Interacts with MICAL and TXNL4/DIM1.

Subcellular Location:
Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm. Cell junction, focal adhesion. Note=Localizes to both the cell nucleus and the cell periphery and is differently localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle.
Enhancer of filamentation 1 p55: Cytoplasm, cytoskeleton, spindle.

Tissue Specificity:
Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues.

Post-translational modifications:
Cell cycle-regulated processing produces four isoforms: p115,p105, p65, and p55. Isoform p115 arises from p105 phosphorylationand appears later in the cell cycle. Isoform p55 arises from p105as a result of cleavage at a caspase cleavage-related site and itappears specifically at mitosis. The p65 isoform is poorlydetected.
Focal adhesion kinase 1 phosphorylates the protein at theYDYVHL motif (conserved among all cas proteins). The SRC familykinases (FYN, SRC, LCK and CRK) are recruited to the phosphorylatedsites and can phosphorylate other tyrosine residues. Ligation ofeither integrin beta-1 or B-cell antigen receptor on tonsillarB-cells and B-cell lines promotes tyrosine phosphorylation and bothintegrin and BCR-mediated tyrosine phosphorylation requires anintact actin network. In fibroblasts transformation with oncogenev-ABL results in an increase in tyrosine phosphorylation.Transiently phosphorylated following CD3 cross-linking and thisphosphorylated form binds to CRK and C3G. A mutant lacking the SH3domain is phosphorylated upon CD3 cross-linking but not uponintegrin beta-1 cross-linking. Tyrosine phosphorylation occurs uponstimulation of the G-protein coupled C1a calcitonin receptor inrabbit. Calcitonin-stimulated tyrosine phosphorylation is mediatedby calcium- and protein kinase C-dependent mechanisms and requiresthe integrity of the actin cytoskeleton.

Similarity:
Belongs to the CAS family.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 4739 Human

Entrez Gene: 18003 Mouse

Entrez Gene: 291044 Rat

Omim: 602265 Human

SwissProt: Q14511 Human

SwissProt: O35177 Mouse

Unigene: 37982 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
超嫩校花被灌醉在线观看 | 久久精品一区二区国产 | 亚洲成人电影在线观看精品国产 | 九九线精品视频在线观看视频 | 午夜性色一区二区三区不卡视频 | 久久8精品亚洲AV无码 | 国产精品亚洲第一区在线 | 国产AV无码专区亚洲A∨毛片 | 中国女人一级毛片 | 欧美三级在线电影免费 | 亚洲精品国产精品国自产! 未满十八岁勿入网站WWW | 久久精品欧美一区二区三区不卡 | 国产精品永久免费视频观看 | 久久久久亚洲Av片无码 | 国产欧美精品123区发布 | 夜夜爽妓女8888888视频 | 18禁国产精品久久久久久久久 | 国内边做边爱完整版免费视频播放 | 娇妻在客厅被朋友玩得呻吟漫画 | 粉色视频在线观看完整版高清免费 | 日韩青草青草久热精品视频在线网站乱码 | 欧美大屁股XXXX高跟欧美黑人 | 欧美成a人片在线观看久 | 日韩AV无码一区二区三区不卡毛片 | 国产日产欧产精品精乱了派 | 又小又紧女MAGNET | 精品国产乱码久久久久软件 | 粉嫩小泬流出白浆 | 欧洲精品A片一区二区免费 国产乱老熟视频乱老熟女51 | 国产AV一区二区三区 | 精品国产髙清在线看国产毛片 | 99re6这里只有精品视频在线观看 | 国产精品禁18久久久夂久 | 日本大胆欧美人术艺术 | 欧美精品久久久久久久小说 | 国产精品久久久久久久福利竹菊 | 亚洲欧美一区二区三区导航 | 国产成人久久精品二三区麻豆 | 久久久久久高清毛片一级黑人免费 | 中文字幕一区视频一线 | 男女啪啪激烈高潮无遮挡 |