亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美人与动性XXXXX杂性,毛片女人十八以上观看
Rabbit Anti-HEF1/APC Conjugated antibody (bs-6265R-APC)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6265R-APC
英文名稱 Rabbit Anti-HEF1/APC Conjugated antibody
中文名稱 APC標(biāo)記的蛋白激酶底物相關(guān)蛋白抗體
別    名 CAS L; Cas like docking; Cas scaffolding protein family member 2; CAS-L; CAS2; CASL; CASL_HUMAN; CASS2; Crk associated substrate related protein; CRK-associated substrate-related protein; dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)); Enhancer of filamentation 1; Enhancer of filamentation 1 p55; HEF 1; HEF1; NEDD 9; NEDD-9; NEDD9; NEDD9 protein; Neural cell expressed developmentally down regulated 9; Neural precursor cell expressed developmentally down regulated 9; Neural precursor cell expressed developmentally down-regulated protein 9; NY REN 12 antigen antibody p105; Protein NEDD9; Renal carcinoma antigen NY-REN-12.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  激酶和磷酸酶  t-淋巴細(xì)胞  b-淋巴細(xì)胞  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 92kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HEF1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.

Function:
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.

Subunit:
Interacts with BCAR3 and SH2D3C. Homodimer. Can heterodimerize with HLH proteins ID2, E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK), adapter protein CRKL and LYN kinase. Interacts with MICAL and TXNL4/DIM1.

Subcellular Location:
Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm. Cell junction, focal adhesion. Note=Localizes to both the cell nucleus and the cell periphery and is differently localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle.
Enhancer of filamentation 1 p55: Cytoplasm, cytoskeleton, spindle.

Tissue Specificity:
Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues.

Post-translational modifications:
Cell cycle-regulated processing produces four isoforms: p115,p105, p65, and p55. Isoform p115 arises from p105 phosphorylationand appears later in the cell cycle. Isoform p55 arises from p105as a result of cleavage at a caspase cleavage-related site and itappears specifically at mitosis. The p65 isoform is poorlydetected.
Focal adhesion kinase 1 phosphorylates the protein at theYDYVHL motif (conserved among all cas proteins). The SRC familykinases (FYN, SRC, LCK and CRK) are recruited to the phosphorylatedsites and can phosphorylate other tyrosine residues. Ligation ofeither integrin beta-1 or B-cell antigen receptor on tonsillarB-cells and B-cell lines promotes tyrosine phosphorylation and bothintegrin and BCR-mediated tyrosine phosphorylation requires anintact actin network. In fibroblasts transformation with oncogenev-ABL results in an increase in tyrosine phosphorylation.Transiently phosphorylated following CD3 cross-linking and thisphosphorylated form binds to CRK and C3G. A mutant lacking the SH3domain is phosphorylated upon CD3 cross-linking but not uponintegrin beta-1 cross-linking. Tyrosine phosphorylation occurs uponstimulation of the G-protein coupled C1a calcitonin receptor inrabbit. Calcitonin-stimulated tyrosine phosphorylation is mediatedby calcium- and protein kinase C-dependent mechanisms and requiresthe integrity of the actin cytoskeleton.

Similarity:
Belongs to the CAS family.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 4739 Human

Entrez Gene: 18003 Mouse

Entrez Gene: 291044 Rat

Omim: 602265 Human

SwissProt: Q14511 Human

SwissProt: O35177 Mouse

Unigene: 37982 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产精品爱啪在线播放 | 亚洲国产婷婷综合在线精品 | 国产精品久久久久精品 | 国产精品99久久精品爆乳 | 欧美精品黄页在线观看视频 | 色欲aⅴ精品一区二区三区浪潮 | 久久久久人妻精品一区5555 | 男人的天堂免费观看视频 | hot亚洲欧美日韩精品久久视频在线播放 | 一区二区三区在线观看视频 | 久久久久精品国产亚洲av麻豆 | 欧美午夜精品一区二区蜜桃 | 国产全肉乱妇杂乱视频 | 国产大爆乳大爆乳在线播放 | 十八岁污网站在线观看 | 亚洲欧洲日产国码久在线 | 中文字幕网伦射乱中文 | 精品一级毛片免费视频 | 麻豆精产国品一二三产区区别在哪 | 亚洲日韩国产欧美精品 | 欧美日本高清动作片www网站 | 女人高潮喷浆毛片视频 | 日韩人欧美?片内射久久 | 小说区 图片区色 综合区 | 国产精品亚洲综合五月天 | 女人被狂躁到高潮视频免费 | 欧美日韩中文字幕群交视频在线观看 | 狠狠色综合7777久夜色撩人 | 久久国产精品99精国产 | 国产又滑又嫩又白 | 国产伦精品一区二区免费 | 999国内精品永久免费观看 | 国产精品jizz在线观看老狼 | 日本老妇一级特黄aa大片 | AV蜜臀在线网站 | 精品21国产成人综合网在线 | 日韩在线视频播放一区二区三区 | 色欲aⅴ精品一区二区三区浪潮 | 麻豆精品国产自产在线观看 | 91人妻无码精品一区二区毛片 | 国产精品jizz在线观看老狼 |