亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
国产精品精品久久久久久,中文美女乱婬试看视频
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-SQSTM1/P62/PE Conjugated antibody (bs-2951R-PE)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2951R-PE
英文名稱 Rabbit Anti-SQSTM1/P62/PE Conjugated antibody
中文名稱 PE標記的泛素結合蛋白P62抗體
別    名 A170; EBI 3 associated protein of 60 kDa; EBI3 associated protein of 60 kDa; EBI3-associated protein of 60 kDa; EBIAP; MGC127197; ORCA; OSF-6; Osi; OSIL; Oxidative stress induced like; p60; p62; p62B; Paget disease of bone 3; PDB 3; PDB3; Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa; Phosphotyrosine independent ligand for the Lck SH2 domain p62; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; PKC-zeta-interacting protein; Protein kinase C-zeta-interacting protein; Sequestosome 1; Sequestosome-1; SQSTM 1; SQSTM_HUMAN; Sqstm1; STAP; STONE14; Ubiquitin binding protein p62; Ubiquitin-binding protein p62; ZIP 3; ZIP; ZIP3  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  染色質和核信號  信號轉導  細胞凋亡  轉錄調(diào)節(jié)因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SQSTM1/p62
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.

Function:
Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.

Subunit:
Cytoplasm. Late endosome. Nucleus. Endoplasmic reticulum. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum.

Subcellular Location:
Cytoplasm. Late endosome. Nucleus. Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Phosphorylated. May be phosphorylated by PRKCZ (By similarity). Phosphorylated in vitro by TTN.

DISEASE:
Defects in SQSTM1 are a cause of Paget disease of bone (PDB) [MIM:602080]. PDB is a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts. Manifestations of the disease include bone pain, deformity, pathological fractures, deafness, neurological complications and increased risk of osteosarcoma. PDB is a chronic disease affecting 2 to 3% of the population above the age of 40 years.

Similarity:
Contains 1 OPR domain.
Contains 1 UBA domain.
Contains 1 ZZ-type zinc finger.

Database links:

Entrez Gene: 8878 Human

Entrez Gene: 18412 Mouse

Entrez Gene: 113894 Rat

Omim: 601530 Human

SwissProt: Q13501 Human

SwissProt: Q64337 Mouse

SwissProt: O08623 Rat

Unigene: 709030 Human

Unigene: 40828 Mouse

Unigene: 107103 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
一色屋精品亚洲香蕉网站 | 麻豆精品一区二正一三区 | 国产永久一区二区三区 | 少妇性活BBBBBBBBB四川 | 扒开老师大腿猛进AAA片软件 | 国产精品禁18久久久夂久 | 亚洲妇女熟BBW | 无码专区—VA亚洲V天堂麻豆 | 在线综合亚洲欧美网站无弹窗 | 国产极品久久久久极品1000 | 国产日韩欧美一区二区东京热 | 婷婷色婷婷开心五月四房播播久久 | 日本最新精品视频在线播放 | 最近免费中文字幕大全高清大全1 | 少妇精品无码一区二区三区 | 国产普通话刺激视频在线播放 | 日本亚洲一区二区三区 | 直接看的av网址免费的 | 亚洲AV福利天堂一区二区三 | 久久久久亚洲AV成人人人 | 久久这里只有精品1 | 91免费精品国偷自产在线不卡 | 亚洲色欲国产综合久久天堂 | 欧美日韩激情在线一区二区三区 | 18禁美女裸体无遮挡免费观看国产 | 牛牛本精品99久久精品88m | 人妻熟妇久久久久久精品无码 | 国产午夜无码精品免费看浪潮 | 久久亚洲AⅤ精品网站 | 日韩AV毛片精品久久久 | onlyfans辛尤里福利视频 | 亚洲午夜成人精品无码91 | 欧美成人性色生活18黑人 | 亚洲激情无码一区二区三区 | 欧美在线成人午夜影视 | 欧美日韩视频在线视频二区 | 日本丰满熟妇被捏出奶水 | 大尺度很黄很肉的小说 | 久久国产精品免费观看 | 国产精品后入内射日本在线观看 | 又小又紧女MAGNET |