亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
精品综合久久久久久88,内射少妇36P九色
Rabbit Anti-APEX2/Cy5 Conjugated antibody (bs-6587R-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6587R-Cy5
英文名稱 Rabbit Anti-APEX2/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的嘌呤嘧啶核酸內(nèi)切酶2抗體
別    名 AP endonuclease 2; AP endonuclease XTH2; APE 2; APE2; APEX 2; APEX L2; APEX nuclease (apurinic/apyrimidinic endonuclease) 2; APEX Nuclease 2; APEX nuclease like 2; APEXL 2; APEXL2; Apurinic apyrimidinic endonuclease 2; Apurinic/apyrimidinic endonuclease 2; Apurinic/apyrimidinic endonuclease like 2; C430040P13Rik; DNA (apurinic or apyrimidinic site) lyase 2; XTH 2; XTH2; APEX2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  染色質(zhì)和核信號(hào)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Dog, Cow, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human APEX2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).

Function:
Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.

Subunit:
Interacts with PCNA; this interaction is triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA.

Subcellular Location:
Nucleus. Cytoplasm. Mitochondrion (Probable). Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.

Tissue Specificity:
Highly expressed in brain and kidney. Weakly expressed in the fetal brain.

Similarity:
Belongs to the DNA repair enzymes AP/ExoA family.

Database links:

Entrez Gene:  Human

Entrez Gene: 77622 Mouse

Entrez Gene: 289662 Rat

Omim: 300773 Human

SwissProt: Q9UBZ4 Human

SwissProt: Q68G58 Mouse

Unigene: 659558 Human

Unigene: 440275 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产精品天干天干综合网 | 免费又黄又爽1000禁片 | 性一交一无一伦一精一品视频 | 免费午夜无码18禁无码影视 | 嗯~啊~快点死我女女 | 公与淑婷厨房猛烈进出视频韩国 | 国产又黄又爽无遮挡动态图 | 国产精品一区在线麻豆 | 99视频精品在线 | 熟妇丰满大屁股在线播放BBW | 国语的ZOOFILIA杂交VIDEOS新 | 国产成人综合亚洲欧美在线观看 | 人妻人人澡人人添人人爽冫 | 久久久久免费看精品国产成人一区二区三区 | 一本色道久久88综合亚洲精品 | 国产午夜免费视频片夜色 | 午夜欧美日韩精品久久久久久 | 丁香五月亚洲综合深深爱 | 善良娇妻在老汉跨下呻吟 | a色毛片免费视频 | 中文字幕无码一区二区免费 | 强奸伦久久久久久久久久久特级av | 国产高潮精品呻吟久久∧v无码 | 亚洲乱码国产乱码精品精乡村 | 亚洲熟女乱色一区二区三区 | 久久国内精品自在自线 | 黄网站色视频大全免费观看 | 少妇被黑人到高潮喷出白浆 | 欧美日韩1卡2卡3卡免费高清中文精品字幕 | 国产精品久久久久久久人人看 | 色欲精品国产一区二区三区AV | 亚洲AV成人无码一二三在线观看 | 免费可以看黄的视频s色 | 九九九免费观看视频 | 亚洲精品宾馆在线精品酒店 | 亚洲熟妇一区二区三区 | √天堂中文www官网 粉嫩METART人体欣赏 | 亚洲和欧洲一码二码区别7777 | 51视频精品全部免费的意义在哪里 | 日韩人妻高清精品专区 | 最近中文字幕高清字幕MV |