亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产美女主播一级成人毛片 ,亚洲日韩乱码中文无码蜜桃臀网站,日韩在线视频一区二区三区
Rabbit Anti-APEX2/PE-Cy5.5 Conjugated antibody (bs-6587R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-6587R-PE-Cy5.5
英文名稱 Rabbit Anti-APEX2/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的嘌呤嘧啶核酸內(nèi)切酶2抗體
別    名 AP endonuclease 2; AP endonuclease XTH2; APE 2; APE2; APEX 2; APEX L2; APEX nuclease (apurinic/apyrimidinic endonuclease) 2; APEX Nuclease 2; APEX nuclease like 2; APEXL 2; APEXL2; Apurinic apyrimidinic endonuclease 2; Apurinic/apyrimidinic endonuclease 2; Apurinic/apyrimidinic endonuclease like 2; C430040P13Rik; DNA (apurinic or apyrimidinic site) lyase 2; XTH 2; XTH2; APEX2_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  染色質(zhì)和核信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Dog, Cow, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human APEX2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).

Function:
Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.

Subunit:
Interacts with PCNA; this interaction is triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA.

Subcellular Location:
Nucleus. Cytoplasm. Mitochondrion (Probable). Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.

Tissue Specificity:
Highly expressed in brain and kidney. Weakly expressed in the fetal brain.

Similarity:
Belongs to the DNA repair enzymes AP/ExoA family.

Database links:

Entrez Gene:  Human

Entrez Gene: 77622 Mouse

Entrez Gene: 289662 Rat

Omim: 300773 Human

SwissProt: Q9UBZ4 Human

SwissProt: Q68G58 Mouse

Unigene: 659558 Human

Unigene: 440275 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
亚洲AV色香蕉一区二区三区 | 狠狠色噜噜狠狠狠狠色综合久 | 日本又黄又爽又色又刺激的视频 | 美女隐私黄www视频 日本电影亚洲欧美精品素人 | 最近中文字幕mv免费视频 | 色欲久久久久久综合网精品 | 日韩精品一区二区三区免费视频 | 性生生活大片又黄又 | 日本一二三区视频在线 | 欧美精品69videosex性欧美 | 久久国产精品高潮一级毛片 | 亚洲AV无码乱码在线观看性色 | 国产日韩精品中文字无码国产精品 | 日韩一区二区三区AV | 加勒比黑人喝羽月希奶水 | 中文字幕网伦射乱中文 | 精品人妻aV中文字幕乱码 | 欧美不卡视频一区发布 | 日本一二三区视频在线 | 国产欧美精品一区二区色综合 | 国产午夜精品理论片小yo奈 | 狠狠色丁香久久婷婷综合_中 | 国产精品久免费的黄网站 | 美一女一无一伦一精一品 | 亚洲AV无码国产精品久久久不卡 | 18禁美女裸体无遮挡免费观看国产 | 久久久久国产美女免费网站 | 色一伦一情一区二区三区 | a级高清观看视频在线看 | 久久久久人妻精品一区5555 | 国产在线观看99 | 成人午夜性A级毛片免费 | 免费国产黄网站在线观看可以下载 | 日本产品和韩国产品哪个好99 | 无码国产精品一区二区免费式芒果 | 粉嫩国产15xxxxx | 日本强好片久久久久久AAA | 无码AV动漫精品一区二区免费 | 鲁一鲁AV2019在线 | 91精品国产高清一区二区三蜜臀 | 日韩精品久久久久久福利 |