亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
成人区人妻精品一区二区不卡视频,成人午夜国产内射主播
Rabbit Anti-CSEN/PE-Cy5.5 Conjugated antibody (bs-9853R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-9853R-PE-Cy5.5
英文名稱 Rabbit Anti-CSEN/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的鉀通道相互作用蛋白3抗體
別    名 A type potassium channel modulatory protein 3; A-type potassium channel modulatory protein 3; Calsenilin; CSEN; CSEN_HUMAN; DRE antagonist modulator; DRE-antagonist modulator; DREAM; EF hand transcription factor; KCHIP 3; KCHIP3; KCNIP 3; KCNIP3; Kv channel interacting protein 3; Kv channel-interacting protein 3; MGC18289; Potassium channel interacting protein 3; Presenilin binding protein; R74849.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 心血管  神經(jīng)生物學(xué)  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CSEN
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

Function:
Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and probably KCND3 trafficking to the cell surface.
May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.

Subunit:
inds to DNA as a homomultimer. Dimerization is induced by binding to calcium. Component of heteromultimeric potassium channels. Interacts with KCND2 and KCND3. Interacts with the C-terminus of PSEN1 and PSEN2 and with PSEN2 CTF subunit. Associates with KCN1.

Subcellular Location:
Cytoplasm. Cell membrane; Lipid-anchor. Endoplasmic reticulum. Golgi apparatus. Nucleus (Probable). Note=Also membrane-bound, associated with the plasma membrane. In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi.

Tissue Specificity:
Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.

Post-translational modifications:
Palmitoylated. Palmitoylation enhances association with the plasma membrane.
Proteolytically cleaved by caspase-3.
Phosphorylation at Ser-63 inhibits cleavage by CASP3.

Similarity:
Belongs to the recoverin family.
Contains 4 EF-hand domains.

Database links:

Entrez Gene: 30818 Human

Omim: 604662 Human

SwissProt: Q9Y2W7 Human

Unigene: 437376 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
日韩欧美一区二区三区在线视频 | 日韩欧美精品在线观看 | 欧美亚洲另类丝袜自拍动漫 | 欧美乱妇狂野欧美在线视频 | 黄色视频免费在线观看 | 国产高潮国产高潮久久久无码 | 国产女同一区二区三区五区 | 国产91在线视频观看 | 又白又嫩毛又多15P 伦人伦 XXX国语对白 | 一区二区高清无码电影 | 国产成人一区二区国产 | 少妇荡乳情欲办公室456视频 | 黄网站色视频大全免费观看 | 最近中文字幕在线中文视频 | 视频一区在线免费观看 | 韩国免费一级a一片在线播放 | EEUSS影院WWWeeusshk | 55夜色66夜色| 国产麻豆精品久久一二三 | 天堂资源官网在线资源 | 欧美精品人人做天天操夜夜操 | 久久成人无码国产免费播放 | a级毛片无码免费真人久久 国产精品视频一区二区三区不卡 | 麻豆一区二区三区蜜桃免费 | 黄瓜茄子樱桃视频app | 内射国产老熟女综合导航 | 天堂资源官网在线资源 | 乌克兰粗大猛烈18P 最新国产毛2卡3卡4卡 | 风情韵味人妻HD | 后入骚妇内射AV | AV色欲无码人妻中文字幕 | 日韩欧美一区二区中文字幕 | 91精品视频网站 | 女老板又大又紧水又多 | 久久久综合亚洲色一区二区三区 | 国产福利一区二区三区在线观看 | WWW国产精品内射熟女 | 欧美日韩成人VA精品一区二区三区不卡 | 欧美又大粗又爽又黄大片视频 | 欧美一区二区日韩一区二区 | 国产亚洲精品精品精品 |