亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产一级特黄A片高潮片,欧美日韩精品一区二区在线播放蜜臀
Rabbit Anti-Doublecortin/BF488 Conjugated antibody (bs-1269R-BF488)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1269R-BF488
英文名稱 Rabbit Anti-Doublecortin/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的雙皮質(zhì)素抗體
別    名 Doublecortex; DBCN; Dbct; DC; DCX; Doublin; Lis X; Lissencephalin X; Lissencephaly X linked; Lissencephaly X linked doublecortin; LISX; Neuronal migration protein doublecortin; SCLH; XLIS.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞粘附分子  細(xì)胞類型標(biāo)志物  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Doublecortin
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Neuronal Marker

Doublecortin (DCX) is a microtubule-associated protein expressed almost exclusively in immature neurons. Neuronal precursors begin to express DCX shortly after exiting the cell cycle, and continue to express DCX for 2-3 weeks as the cells mature into neurons. Downregulation of DCX begins after 2 weeks, and occurs at the same time that these cells begin to express, a marker for mature neurons. Due to the nearly exclusive expression of DCX in developing neurons, this protein has been used increasingly as a marker for neurogenesis. Indeed, the levels of DCX expression increase in response to exercise, which occurs in parallel with increased BrdU labelling, currently a "gold standard" in measuring neurogenesis.

Function:
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of a overlapping, but distinct, signaling pathways that promote neuronal migration.

Subunit:
Interacts with tubulin.

Subcellular Location:
Cytoplasm. Cell projection. Note=Localizes at neurite tips.

Tissue Specificity:
Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.

Post-translational modifications:
Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind mirotubules.

DISEASE:
Defects in DCX are the cause of lissencephaly X-linked type 1 (LISX1) [MIM:300067]; also called X-LIS or LIS. LISX1 is a classic lissencephaly characterized by mental retardation and seizures that are more severe in male patients. Affected boys show an abnormally thick cortex with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone, seizures and severe to profound psychomotor retardation. Female patients display a less severe phenotype referred to as 'doublecortex'.
Defects in DCX are the cause of subcortical band heterotopia X-linked (SBHX) [MIM:300067]; also known as double cortex or subcortical laminar heterotopia (SCLH). SBHX is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in the central white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing normal.
Note=A chromosomal aberration involving DCX is found in lissencephaly. Translocation t(X;2)(q22.3;p25.1).

Similarity:
Contains 2 doublecortin domains.

Database links:

Entrez Gene: 1641 Human

Entrez Gene: 13193 Mouse

Entrez Gene: 84394 Rat

Omim: 300121 Human

SwissProt: O43602 Human

SwissProt: O88809 Mouse

SwissProt: Q9ESI7 Rat

Unigene: 34780 Human

Unigene: 12871 Mouse

Unigene: 121471 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)細(xì)胞標(biāo)志物(Neuronal Marker)
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
欧美日韩一级久久久久久免费看 | 强行内射无码毛片视频 | 亚洲综合另类欧美久久久久精品 | 色欲aⅴ精品一区二区三区浪潮 | 日本一卡二卡不卡视频查询 | 99精品一级欧美片免费播放 | 一性一交一伦一色一按—摩 | 亚洲熟妇无码乱子AV电影 | 国产v亚洲v天堂a无码 | 免费精品国产自产拍在线观看图片 | 中文字幕一区在线观看视频 | 国产精品毛片在线完整版的 | 中文无码AV人妻一级字幕VR | 色欲狠狠躁天天躁无码中文字幕 | 久久丁香婷深爱五月天网 | 中文字幕人妻少妇伦伦伦 | 狠狠躁日日躁夜夜躁2022麻豆 | 艳妇乳肉豪妇荡乳AV无码福利 | 免费无码高潮流白浆视频 | 日韩毛片AV无码免费一区二区三区 | 人人揉人人捏人人爽五月天 | 日韩成人大屁股内射喷水 | 男人女人爽好猛好痛视频 | 日本夜爽爽一区二区三区 | 国产婬乱a一级毛片多女 | 性一交一无一伦一精一品视频 | 久久久久久久精品国产亚洲蜜臀 | 连续高潮抽搐爽死喷水流白浆无码 | 非州黄色视频免费网站 | 国产无套内射普通话对白 | 精品一区二区三区免费观看 | 久久精品欧美一区二区三区不卡 | 久久久久99狠狠综合久久 | 欧美成人一区二区三区在线视频 | AV无码播放一级毛片免费野外 | 国产欧美日韩一区二区三区 | 91久久久精品人妻无码专区不卡 | 亚洲国产精品人人爽夜夜爽 | 日韩综合在线观看 | 久久精品国产亚洲A片高清不卡 | 97人人爽人人爽爽人人一区二区 |