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Rabbit Anti-Prohibitin/PE-Cy5.5 Conjugated antibody (bs-1449R-PE-Cy5.5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-1449R-PE-Cy5.5
英文名稱 Rabbit Anti-Prohibitin/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的抑制素/腫瘤抑制因子抗體
別    名 Mitochondrial Marker; PHB; prohibitin; PHB1; Prohibitin - Mitochondrial Marker; PHB_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  染色質(zhì)和核信號  細(xì)胞凋亡  細(xì)胞類型標(biāo)志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Dog, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 30kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Prohibitin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Function:
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

Subunit:
Interacts with PHB2. Interacts with STOML2.

Subcellular Location:
Mitochondrion inner membrane.

Tissue Specificity:
Widely expressed in different tissues.

Similarity:
Belongs to the prohibitin family.

Database links:

Entrez Gene: 5245 Human

Entrez Gene: 18673 Mouse

Entrez Gene: 25344 Rat

Omim: 176705 Human

SwissProt: P35232 Human

SwissProt: P67778 Mouse

SwissProt: P67779 Rat

Unigene: 514303 Human

Unigene: 263862 Mouse

Unigene: 29754 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Prohibitin(phb)基因是一種有效的腫瘤抑制基因,廣泛分布于不同種屬的各種生物細(xì)胞中,它所編碼的產(chǎn)物Prohibitin(PHB)蛋白結(jié)構(gòu)保守,既存在于線粒體內(nèi)膜上,發(fā)揮分子伴侶作用,也存在于細(xì)胞核內(nèi),具有負(fù)性轉(zhuǎn)錄調(diào)控作用,因而對細(xì)胞代謝、生長、分化、衰老以及凋亡等諸多方面發(fā)揮 著重要的調(diào)控作用,可能與某些腫瘤和退行性疾病的發(fā)生有關(guān)。
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