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Rabbit Anti-GATA4/AP Conjugated antibody (bs-1778R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1778R-AP
英文名稱 Rabbit Anti-GATA4/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的GATA結(jié)合蛋白4抗體
別    名 GATA binding factor 4; GATA 4; GATA4; GATA-4; Transcription factor GATA-4; GATA-binding factor 4; Gata4; GATA4_HUMAN; GATA-binding factor 4.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  發(fā)育生物學(xué)  干細胞  轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 WB=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GATA-4 (301-332aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
GATA4 is a 46 kDa member of the GATA family of zinc finger containing transcription factors that is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs.

Function:
Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement.

Subunit:
Interacts with ZNF260. Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes.

Subcellular Location:
Nucleus.

Post-translational modifications:
Methylation at Lys-300 attenuates transcriptional activity.

DISEASE:
Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.

Similarity:
Contains 2 GATA-type zinc fingers.

Database links:

Entrez Gene: 2626 Human

Entrez Gene: 14463 Mouse

Entrez Gene: 54254 Rat

Omim: 600576 Human

SwissProt: P43694 Human

SwissProt: Q08369 Mouse

SwissProt: P46152 Rat

Unigene: 243987 Human

Unigene: 247669 Mouse

Unigene: 26251 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GATA-4屬于轉(zhuǎn)錄調(diào)節(jié)性因子,表達在心組織、胃腸道組織中,并調(diào)節(jié)該類T細胞的發(fā)育和功能。
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