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Rabbit Anti-Antithrombin III /SERPINC1/BF647 Conjugated antibody (bs-1636R-BF647)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1636R-BF647
英文名稱 Rabbit Anti-Antithrombin III /SERPINC1/BF647 Conjugated antibody
中文名稱 BF647標(biāo)記的抗凝血酶3抗體
別    名 AntithrombinIII; Antithrombin III; AT 3; AT III; AT3; ATIII; MGC22579; Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1; Serine Proteinase Inhibitor Clade C Member 1; SERPIN C1; Serpin peptidase inhibitor clade C (antithrombin) member 1; SERPINC1; ATH III.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 心血管  細(xì)胞生物  免疫學(xué)  合成與降解  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Antithrombin III
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009].

Function:
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Subunit:
Forms protease inhibiting heterodimer with TMPRSS7.

Subcellular Location:
Secreted, extracellular space.

Tissue Specificity:
Plasma.

Post-translational modifications:
Phosphorylation sites are present in the extracellular medium.

Similarity:
Belongs to the serpin family.

Database links:

Entrez Gene: 462 Human

Entrez Gene: 11905 Mouse

Entrez Gene: 304917 Rat

Omim: 107300 Human

SwissProt: P01008 Human

SwissProt: P32261 Mouse

Unigene: 75599 Human

Unigene: 260770 Mouse

Unigene: 204806 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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