亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美日韩中文字幕群交视频在线观看,337p日本欧洲亚洲大胆
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-FANCB/BRCA2/Cy5.5 Conjugated antibody (bs-1210R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1210R-Cy5.5
英文名稱 Rabbit Anti-FANCB/BRCA2/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的乳腺癌易感基因2抗體
別    名 BRCA 2; BRCA1/BRCA2 containing complex subunit 2; BRCC 2; BRCC2; Breast and ovarian cancer susceptibility gene early onset; Breast cancer 2 early onset; Breast Cancer 2 tumor suppressor; Breast cancer susceptibility protein BRCA2; Breast cancer type 2 susceptibility protein; FACD; FAD 1; FAD; FAD1; FANCB; FANCD 1; FANCD; FANCD1; Fanconi anemia complementation group D1; Fanconi anemia group D1 protein; OTTHUMP00000018803; OTTHUMP00000042401.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  免疫學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 384kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BRCA2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group B. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Function:
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. In concert with NPM1, regulates centrosome duplication.

Subunit:
Monomer and dimer. Interacts with RAD51; regulates RAD51 recruitment and function at sites of DNA repair. Interacts with DSS1. Interacts with both nonubiquitinated and monoubiquitinated FANCD2; this complex also includes XRCC3 and phosphorylated FANCG. Interacts with WDR16. Interacts with USP11. Interacts with DMC1. Part of a trimeric complex containing BRCA1, BRCA2 and PALB2. Interacts with PALB2. Interacts with BRCA1 only in the presence of PALB2 which serves as the bridging protein. Interacts with ROCK2 and NPM1.

Subcellular Location:
Nuclear protein.

Tissue Specificity:
Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen.

Post-translational modifications:
Phosphorylated by ATM upon irradiation-induced DNA damage. Phosphorylation by CHEK1 and CHEK2 regulates interaction with RAD51. Phosphorylation at Ser-3291 by CDK1 and CDK2 is low in S phase when recombination is active, but increases as cells progress towards mitosis; this phosphorylation prevents homologous recombination-dependent repair during S phase and G2 by inhibiting RAD51 binding.
Ubiquitinated in the absence of DNA damage; this does not lead to proteasomal degradation. In contrast, ubiquitination in response to DNA damage leads to proteasomal degradation.

DISEASE:
Defects in BRCA2 are a cause of susceptibility to breast cancer (BC). A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Defects in BRCA2 are the cause of pancreatic cancer type 2 (PNCA2) [MIM:613347]. It is a malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

Similarity:
Contains 8 BRCA2 repeats.

Database links:

Entrez Gene: 2187 Human

Omim: 300515 Human

SwissProt: Q8NB91 Human

Unigene: 554740 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

BRCA2蛋白與DNA修復(fù)和重組有關(guān), 乳腺癌易感基因其突變和家族性乳腺癌、卵巢癌的發(fā)病有關(guān)。
BRCA2是新近發(fā)現(xiàn)的一個抑癌基因,它在流行病學上與早期發(fā)現(xiàn)的BRCA1有許多相似之處。有學者發(fā)現(xiàn):BRCA2在其它BRCA2突變的家族中也發(fā)現(xiàn)多發(fā)有結(jié)腸癌、肺癌、輸尿管癌、腦瘤、胰腺癌和白血病等。BRCA2突變家族中這種腫瘤的多樣性在其它研究中也有報道。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
毛片无码免费无码播放 | 榴莲视频在线看一日韩 | 又黄又湿真实网站不付费 | 国产日韩欧美三级 | 亚洲精品V天堂中文字幕 | 青青草97国产精品免费观看 | 男女激情无遮挡免费视频 | 成人免费大片黄在线播放 | 久久久久久久成人午夜精品福利 | 国产高潮精品呻吟久久∧v无码 | 色欲日本人妻久久久久久综合 | 亚洲综合另类欧美久久久久精品 | 黑白配黑粗硬大疯狂乱叫 | 欧洲性开放大片免费观看视频 | 无码人妻熟妇av又粗又大 | 18视频入口网站在线看 | 日日碰狠狠添天天爽无码av | 久久线看在观草草青青脱裤 | 一本久道久久综合狠狠躁AV | 内射白浆一区二区在线观看 | 亚洲国产18成人中文字幕久久久久无码av | 日本夜爽爽一区二区三区 | 亚洲人人夜夜澡人人爽 | 两个人看的www视频中文字幕 | 免费精品美女久久久久久久久久 | 东北女人一级毛片 | 欧洲VIDEOS重口变态深 | 成人免费精品网站在线观看影片 | AV无码人妻一区二区三区在线 | aaaaa级毛片 毛片线看免费观看 | 国产精品99久久久精品无码 | 国产女主播喷水视频在线观看 | 国产成a人大片在线观看 | 国产日产欧美一区二区蜜桃 | 给我免费播放片高清在线观看 | 午夜国产精品秘 入口竹菊 一区二区日本视频 | 免费精品一区二区三区在线观看 | 免费毛片网站在线观看 | 国产思妍小仙女一二区 | 亚洲精品自产拍在线观看 | 荡公乱妇蒂芙尼中文字幕 |