亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲国产精品人人做人人爽,伊人yinren6综合网色狠狠
Rabbit Anti-Frizzled 2/PE-Cy5.5 Conjugated antibody (bs-6623R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-6623R-PE-Cy5.5
英文名稱 Rabbit Anti-Frizzled 2/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的Wnt信號受體FZD2蛋白抗體
別    名 Frizzled homolog 2; Frizzled-2; Frizzled2; Fz 2; Fz-2; Fz2; FZD 2; FZD2; FZD2_HUMAN; FzE 2; FzE2; hFz 2; hFz2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  G蛋白偶聯(lián)受體  細(xì)胞表面分子  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Frizzled 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled as well as several secreted mammalian frizzled-related proteins (FRPs) have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. Expression of frizzled-2 can be observed in the fetal kidney and lung and in the adult ovary and colon. The Wnt/cGMP/Ca2+ pathway is mediated by frizzled-2 . It binds Wnt proteins and signals by activating the release of stored calcium. Expression of frizzled-2 is regulated by Angiotensin II. Activated frizzled-2 suppresses the activity of protein kinase G, and activates NFAT-dependent transcription, the phosphatidylinositol pathway and calcium sensitive enzymes.

Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular Location:
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.

Post-translational modifications:
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity).

Similarity:
Belongs to the G-protein coupled receptor Fz/Smo family.
Contains 1 FZ (frizzled) domain.

Database links:

Entrez Gene: 2535 Human

Entrez Gene: 57265 Mouse

Entrez Gene: 64512 Rat

Omim: 600667 Human

SwissProt: Q14332 Human

SwissProt: Q9JIP6 Mouse

SwissProt: Q08464 Rat

Unigene: 142912 Human

Unigene: 597264 Human

Unigene: 36416 Mouse

Unigene: 92324 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产不卡高清在线观看视频 | 岛国一区二区三区 | 日韩在线视频一区二区三区 | 玩50岁四川熟女大白屁股直播 | 动漫AV网站免费观看 | 扒开双腿猛进入爽爽在线观看 | 丰满岳妇乱一区二区三区 | 丰满爆乳肉感一区二区三区 | 欧美日韩国产综合视频在线观看 | 中文字幕久久久久久久免费 | 欧洲性开放大片免费观看视频 | 欧美性生活视频免费播放网址大全观看 | 三级在线看中文字幕完整版 | 97夜夜澡人人爽人人喊中国片 | 亚洲AV福利天堂一区二区三 | 欧美另类69xxxxx | 欧美两根一起进3p在线观看 | 91天堂最新在线观看 | 欧美日韩视频一视频二视频三 | 国产高清国内精品福利色噜噜 | 欧美日韩不卡高清在线看 | 91精品国产福利资源在线观看麻豆 | 国产精品免费看久久久8 | 国产精品高潮视亚洲乱码 | √天堂中文www官网在线 | 最近中文字幕高清字幕mv | 久久一区二区三区精华液使用方法 | 国产超碰人人做人人爱ⅴA 一本久久a久久精品亚洲 | 欧美最猛激情性AAAAA | 韩国一区二区视频 | 午夜尤物禁止18点击进入 | 久久精品国产精品亚洲色婷婷 | 性生生活色欲片性按摩 | 人妻少妇久久中文字幕 | 黄色网站免费在线观看 | 最近日本字幕MV高清在线观看 | XXX2高清在线观看免费视频 | 久久99人妻无码精品一区二区 | 爽死你个放荡粗暴小淫货漫画 | 一区国产传媒国产精品 | 成人网站在线免费观看 |