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Rabbit Anti-Insig2/FITC Conjugated antibody (bs-6625R-FITC)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6625R-FITC
英文名稱 Rabbit Anti-Insig2/FITC Conjugated antibody
中文名稱 FITC標(biāo)記的胰島素誘導(dǎo)基因2抗體
別    名 Hypothetical protein INSIG2; INSIG 2; INSIG-2; INSIG 2 membrane protein; INSIG2 membrane protein; Insulin induced gene 2; Insulin induced gene 2 protein; Insulin induced protein 2; MGC26273; INSI2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  糖尿病  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Insig2 (81-130aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Insig2 is highly similar to the protein product encoded by gene Insig1. Both Insig1 protein and Insig2 protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.

Function:
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.

Subunit:
Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139.

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein.

Similarity:
Belongs to the INSIG family.

Database links:

Entrez Gene: 51141 Human

Entrez Gene: 72999 Mouse

Entrez Gene: 288985 Rat

Omim: 608660 Human

SwissProt: Q9Y5U4 Human

SwissProt: Q91WG1 Mouse

SwissProt: Q80UA9 Rat

Unigene: 7089 Human

Unigene: 27136 Mouse

Unigene: 486216 Mouse

Unigene: 16736 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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