亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
男人天堂网在线视频观看,一级午夜理论片日本中文在线,jk黑色丝袜美腿老师啪啪
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Vinculin/RBITC Conjugated antibody (bs-6640R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6640R-RBITC
英文名稱 Rabbit Anti-Vinculin/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的粘著斑蛋白抗體
別    名 CMD1W; CMH15; Epididymis luminal protein 114; HEL114; Metavinculin; MV; MVCL; OTTHUMP00000019861; OTTHUMP00000019862; VCL; VINC; VINC_HUMAN。  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  信號轉導  細胞粘附分子  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 125kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Vinculin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Function:
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

Subunit:
Exhibits self-association properties. Interacts with NRAP and SORBS1 (By similarity). Interacts with TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Metavinculin is muscle-specific.

Post-translational modifications:
Phosphorylated; on serines, threonines and tyrosines. Phosphorylation on Tyr-1133 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques (By similarity).
Aceylated; mainly by myristic acid but also small amount of palmitic acid (By similarity).

DISEASE:
Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) [MIM:611407]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in VCL are the cause of cardiomyopathy familial hypertrophic type 15 (CMH15) [MIM:613255]. It is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Similarity:
Belongs to the vinculin/alpha-catenin family.

Database links:

Entrez Gene: 7414 Human

Entrez Gene: 22330 Mouse

Entrez Gene: 305679 Rat

Omim: 193065 Human

SwissProt: P18206 Human

SwissProt: Q64727 Mouse

SwissProt: P85972 Rat

Unigene: 643896 Human

Unigene: 279361 Mouse

Unigene: 164613 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
特级毛片全部免费播放免下载 | 免费一级特黄欧美大片久久网 | 国产猛男猛女超爽免费视频 | 久久刺激cijilu福利72 | 国内精品一级毛片免费看 | 国产一级第一级毛片 | 久久精品综合网人人妻 | 毛片基地看看成人免费 | 国产美女69视频免费观看 | 国产一级 级内射视频 | 国产又爽又黄又爽又刺激 | 女网址www女视频 | 欧美人妻中文字幕乱码在线 | a级全黄试频试看30分钟 | 香港三级精品三级在线专区 | 久久久久成人精品无码国产一区 | 又硬又粗又长又爽免费看 | 精品亚洲A∨无码一区二区三区 | 伊人久久大香线蕉综合色狠狠 | 国产乱妇乱子视频在线播放国产 | 免费看国产曰批40分钟 | 一本三道a无线码一区v小说 | 国产在线观看免费观看不卡 | 好大好爽好猛我要喷水了视频 | 精品一区二区三区在线成人 | 91偷伦一区二区三区蜜臀 | 国内精品久久久久影院老司 | 亚洲91无码精品一区在线播放 | 中文字幕久久久久久一区二区三区 | 亚洲人妻少妇av资源网站 | 男女上下抽搐~嗯~啊~ | 噜噜色青草久久丁香伊人 | 成片免费观看视频潢片 | 亚洲成a人v欧美综合天堂下载 | 亚洲欧美卡通动漫丝袜 | 一色屋精品亚洲香蕉网站 | 国产综合视频在线观看一区 | 日本又黄又裸一级大黄裸片 | 国产日产欧产精品精品 | 一本色道久久综合亚洲精品加 | 免费麻花传媒剧国产MV |